Cerebral malaria (CM) is an acute encephalopathy caused by the malaria parasite
Plasmodium falciparum, which develops in a small minority of infected patients and is …

Plasmodium falciparum causes the most severe and fatal form of malaria in humans with
over half a million deaths each year. Cerebral malaria, a complex neurological syndrome of …

Leukocyte recruitment from the vasculature into tissues is a crucial component of the
immune system but is also key to inflammatory disease. Chemokines are central to this …

Monocytes are a subset of cells that are categorized together with dendritic cells (DCs) and
macrophages in the mononuclear phagocyte system (MPS). Despite sharing several …

The kynurenine pathway (KP) is the major metabolic pathway of the essential amino acid
tryptophan (TRP). Stimulation by inflammatory molecules, such as interferon-γ (IFN-γ), is the …

Robust tools for analysing gene function in Plasmodium parasites, which are the causative
agents of malaria, are being developed at an accelerating rate. Two decades after genetic …

Neutrophils are the most abundant leukocytes in human peripheral blood. They form the first
line of defense against invading foreign pathogens and might play a crucial role in malaria …

Cerebral malaria (CM) is a severe complication of Plasmodium falciparum infection that
results in thousands of deaths each year, mostly in African children. The in vivo mechanisms …

In the murine model of cerebral malaria caused by P. berghei ANKA (PbA), parasite-specific
CD8+ T cells directly induce pathology and have long been hypothesized to kill brain …

While half of the world's population is at risk of malaria, the most vulnerable are still children
under five, pregnant women and returning travelers. Anopheles mosquitoes transmit malaria …