A potentially important aspect in the regulation of tumour metastasis is endocytosis. This
process consists of internalisation of cell-surface receptors via pinocytosis, phagocytosis or …

Prostate cancer has the highest prevalence of any nonskin cancer in the human body, with
similar likelihood of neoplastic foci found within the prostates of men around the world …

Prostate cancer afflicts one man in nine over the age of 65 and represents the most
frequently diagnosed cancer in American men (Coffey 1993). Early detection through serum …

The first tetraspanins were discovered on surface of human leucocytes, but it was rapidly
demonstrated that they had a wider tissue expression. Twenty-six molecules display …

At cell surface microdomains, glycosyl epitopes, carried either by glycosphingolipids, N-or O-
linked oligosaccharides, are recognized by carbohydrate-binding proteins or …

Physically distinguishable microdomains associated with various functional membrane
proteins are one of the major current topics in cell biology. Glycosphingolipids present in …

Background: Raf kinase inhibitor protein (RKIP), an inhibitor of Raf-mediated activation of
mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK), is expressed …

Apoptosis is executed by caspases, which undergo proteolytic activation in response to cell
death stimuli. The apoptotic protease-activating factor 1 (Apaf-1) controls caspase activation …

Since the discovery of nuclear factor-kappa B (NF-κB) in 1986, many studies have been
conducted showing the link between the NF-κB signalling pathway and control of the …

Based on development of various methodologies for isolation and characterization of
glycosphingolipids (GSLs), we have identified a number of GSLs with globo-series or lacto …