In a state of oxidative stress, there is an increase of reactive species, which induce an
altered intracellular signaling, leading to dysregulation of the inflammatory response. The …

Reactive oxygen species (ROS) have been shown to be toxic but also function as signalling
molecules. This biological paradox underlies mechanisms that are important for the integrity …

Various nutritional, behavioral, and pharmacological interventions have been previously
shown to extend life span in diverse model organisms, including Saccharomyces cerevisiae …

This review focuses on the role of oxidative processes in atherosclerosis and its resultant
cardiovascular events. There is now a consensus that atherosclerosis represents a state of …

Recent evidence suggests that calorie restriction and specifically reduced glucose
metabolism induces mitochondrial metabolism to extend life span in various model …

▪ Abstract The cellular stress response is a universal mechanism of extraordinary
physiological/pathophysiological significance. It represents a defense reaction of cells to …

The transcription factor NF-κB plays a major role in coordinating innate and adaptative
immunity, cellular proliferation, apoptosis and development. Since the discovery in 1991 that …

Reactive oxygen or nitrogen species (ROS/RNS) generated endogenously or in response to
environmental stress have long been implicated in tissue injury in the context of a variety of …

Impaired insulin and IGF-1 signaling (iIIS) in C. elegans daf-2 mutants extends life span
more than 2-fold. Constitutively, iIIS increases mitochondrial activity and reduces reactive …

The unique anatomy and physiology of the intestine in conjunction with its microbial content
create the steepest oxygen gradients in the body, which plunge to near anoxia at the luminal …