TALEN were the first easy-to-use genome editing technology and sparked the genome
editing revolution. Their application in multiple species brought targeted mutagenesis to the …

Accurate and rapid detection of pathogenic bacteria is of great importance in the field of
clinical diagnosis and food safety. Current methods for pathogenic bacteria detection have …

The study of epigenetics has greatly benefited from the development and application of
various chemical biology approaches. In this review, we highlight the key targets for …

The epigenetic DNA nucleobases 5-methylcytosine (5mC) and N 4-methylcytosine (4mC)
coexist in bacterial genomes and have important functions in host defence and transcription …

DNA recognition by transcription activator-like effector (TALE) proteins is mediated by
tandem repeats that specify nucleotides through repeat-variable diresidues. These repeat …

Transcription-activator-like effector (TALE) proteins consist of concatenated repeats that
recognize consecutive canonical nucleobases of DNA via the major groove in a …

We report the direct isolation of user-defined DNA sequences from the human genome with
programmable selectivity for both canonical and epigenetic nucleobases. This is enabled by …

For the past decades, gene editing demonstrated the potential of attenuating each of the root
causes of genetic, infectious, immune, cancerous, and degenerative disorders. More …

Transcription-activator-like effectors (TALEs) are programmable DNA binding proteins
widely used for genome targeting. TALEs consist of multiple concatenated repeats, each …

Transcription activator-like effectors (TALEs) recognize DNA through repeat-variable
diresidues (RVDs), and TALE-DNA interactions are sensitive to DNA modifications. Our …