Microvascular dysfunction in diabetes mellitus and cardiometabolic disease

WB Horton, EJ Barrett - Endocrine reviews, 2021 - academic.oup.com
This review takes an inclusive approach to microvascular dysfunction in diabetes mellitus
and cardiometabolic disease. In virtually every organ, dynamic interactions between the …

Hypertension management in patients with cardiovascular comorbidities

L Lauder, F Mahfoud, M Azizi, DL Bhatt… - European Heart …, 2023 - academic.oup.com
Arterial hypertension is a leading cause of death globally. Due to ageing, the rising
incidence of obesity, and socioeconomic and environmental changes, its incidence …

[PDF][PDF] 2013 ESH/ESC Guidelines for the management of arterial hypertension

G Mancia, R Fagard, K Narkiewicz… - Arterial …, 2013 - journals.viamedica.pl
Wytyczne dotyczące nadciśnienia tętniczego opublikowane w 2013 r. przez Europejskie
Towarzystwo Nadciśnienia Tętniczego (ESH) i Europejskie Towarzystwo Kardiologiczne …

SGLT2 inhibitor–induced sympathoinhibition: a novel mechanism for cardiorenal protection

LY Herat, AL Magno, C Rudnicka, J Hricova… - Basic to Translational …, 2020 - jacc.org
Recent clinical trial data suggest a cardiorenal protective effect of sodium glucose
cotransporter 2 (SGLT2) inhibition. We demonstrate that chemical denervation in neurogenic …

Mechanisms of diabetic complications

JM Forbes, ME Cooper - Physiological reviews, 2013 - journals.physiology.org
It is increasingly apparent that not only is a cure for the current worldwide diabetes epidemic
required, but also for its major complications, affecting both small and large blood vessels …

Relevance of sympathetic nervous system activation in obesity and metabolic syndrome

AA Thorp, MP Schlaich - Journal of diabetes research, 2015 - Wiley Online Library
Sympathetic tone is well recognised as being implicit in cardiovascular control. It is less
readily acknowledged that activation of the sympathetic nervous system is integral in energy …

Percutaneous renal denervation in patients with treatment-resistant hypertension: final 3-year report of the Symplicity HTN-1 study

H Krum, MP Schlaich, PA Sobotka, M Böhm, F Mahfoud… - The Lancet, 2014 - thelancet.com
Background Renal denervation (RDN) with radiofrequency ablation substantially reduces
blood pressure in patients with treatment-resistant hypertension. We assessed the long-term …

The role of the autonomic nervous system in the pathophysiology of obesity

D Guarino, M Nannipieri, G Iervasi, S Taddei… - Frontiers in …, 2017 - frontiersin.org
Obesity is reaching epidemic proportions globally and represents a major cause of
comorbidities, mostly related to cardiovascular disease. The autonomic nervous system …

New approaches in the treatment of hypertension

S Oparil, RE Schmieder - Circulation research, 2015 - Am Heart Assoc
Hypertension is the most common modifiable risk factor for cardiovascular disease and
death, and lowering blood pressure with antihypertensive drugs reduces target organ …

Type 2 diabetes mellitus and hypertension: an update

G Lastra, S Syed, LR Kurukulasuriya… - Endocrinology and …, 2014 - endo.theclinics.com
Hypertension (HTN) is present in more than 50% of patients with diabetes mellitus (DM) and
contributes significantly to both microvascular and macrovascular disease in DM (Fig. 1). 1 …