ER-phagy (reticulophagy) defines the degradation of portions of the endoplasmic reticulum
(ER) within lysosomes or vacuoles. It is part of the self-digestion (ie, autophagic) programs …

Autophagy is a lysosome-dependent intracellular degradation system required for various
physiological processes and can be dysregulated in human disease. To understand its …

CRISPR/Cas9 has revolutionized our ability to engineer genomes and conduct genome-
wide screens in human cells,–. Whereas some cell types are amenable to genome …

Viral infections have been proposed to elicit pathological processes leading to the initiation
of T helper 1 (TH1) immunity against dietary gluten and celiac disease (CeD). To test this …

Selective autophagy of organelles is critical for cellular differentiation, homeostasis, and
organismal health. Autophagy of the ER (ER-phagy) is implicated in human neuropathy but …

Targeted protein degradation (TPD) mediates protein level through small molecule induced
redirection of E3 ligases to ubiquitinate neo-substrates and mark them for proteasomal …

Glioblastoma therapies have remained elusive due to limitations in understanding
mechanisms of growth and survival of the tumorigenic population. Using CRISPR-Cas9 …

Biliary epithelial cells (BECs) form bile ducts in the liver and are facultative liver stem cells
that establish a ductular reaction (DR) to support liver regeneration following injury. Liver …

Macroautophagy is an intracellular degradation process that requires multiple autophagy-
related (ATG) genes. In this study, we performed a genome-wide screen using the …

ER-phagy, literally endoplasmic reticulum (ER)-eating, defines the constitutive or regulated
clearance of ER portions within metazoan endolysosomes or yeast and plant vacuoles. The …