The vascular cellular adhesion molecule-1 (VCAM-1) is a protein that canonically
participates in the adhesion and transmigration of leukocytes to the interstitium during …

A central function of the vascular endothelium is to serve as a barrier between the blood and
the surrounding tissue of the body. At the same time, solutes and cells have to pass the …

Mice are the experimental tool of choice for the majority of immunologists and the study of
their immune responses has yielded tremendous insight into the workings of the human …

The endothelium is immunoregulatory in that inhibiting the function of vascular adhesion
molecules blocks leukocyte recruitment and thus tissue inflammation. The function of …

Breast cancer patients often develop locoregional or distant recurrence years after
mastectomy. Understanding the mechanism of metastatic recurrence after dormancy is …

The placenta is the first organ to form during mammalian embryogenesis. Problems in its
formation and function underlie many aspects of early pregnancy loss and pregnancy …

VCAM-1 and ICAM-1 are endothelial adhesion molecules of the Ig gene superfamily that
may participate in atherogenesis by promoting monocyte accumulation in the arterial intima …

In human pregnancy, placental cytotrophoblasts that invade the uterus downregulate the
expression of adhesion receptors that are characteristic of their epithelial origin, and …

Numerous reports document the role of vascular adhesion molecules in the development
and progression of atherosclerosis. Recent novel findings in the field of adhesion molecules …

Focal recruitment of monocytes and lymphocytes is one of the earliest detectable cellular
responses in the formation of lesions of atherosclerosis. This localized accumulation of …