Leishmaniasis in humans: drug or vaccine therapy?

M Ghorbani, R Farhoudi - Drug design, development and therapy, 2017 - Taylor & Francis
Leishmania is an obligate intracellular pathogen that invades phagocytic host cells.
Approximately 30 different species of Phlebotomine sand flies can transmit this parasite …

Recent progress in drug targets and inhibitors towards combating leishmaniasis

S Vijayakumar, P Das - Acta tropica, 2018 - Elsevier
Lesihmaniasis is one of the major neglected tropical disease caused by the parasite of the
genus Leishmania. The disease has more than one clinical forms and the visceral form is …

The novel treatments based on tissue engineering, cell therapy and nanotechnology for cutaneous leishmaniasis

Z Abpeikar, M Safaei, AA Alizadeh, A Goodarzi… - International Journal of …, 2023 - Elsevier
Cutaneous leishmaniasis (CL) is a global public health issue. Conventional treatments have
substantial costs, side effects, and parasite resistance. Due to easy application and …

Nanotechnology-aided diagnosis, treatment and prevention of leishmaniasis

O Kammona, E Tsanaktsidou - International Journal of Pharmaceutics, 2021 - Elsevier
Leishmaniasis is a prevalent parasitic infection belonging to neglected tropical diseases. It is
caused by Leishmania protozoan parasites transmitted by sandflies and it is responsible for …

Identification of BALB/c Immune Markers Correlated with a Partial Protection to Leishmania infantum after Vaccination with a Rationally Designed Multi-epitope …

M Agallou, M Margaroni, E Athanasiou… - PLoS Neglected …, 2017 - journals.plos.org
Background Through their increased potential to be engaged and processed by dendritic
cells (DCs), nanovaccines consisting of Poly (D, L-lactic-co-glycolic acid)(PLGA) …

Chitosan-based particulate systems for drug and vaccine delivery in the treatment and prevention of neglected tropical diseases

S Şenel, S Yüksel - Drug Delivery and Translational Research, 2020 - Springer
Neglected tropical diseases (NTDs) are a diverse group of infections which are difficult to
prevent or control, affecting impoverished communities that are unique to tropical or …

A Leishmania hypothetical protein-containing liposome-based formulation is highly immunogenic and induces protection against visceral leishmaniasis

PAF Ribeiro, DS Dias, MVM Novais, DP Lage… - Cytokine, 2018 - Elsevier
Leishmania proteins have been evaluated as vaccine candidates against leishmaniasis;
however, most antigens present low immunogenicity and need to be added with immune …

Vaccines for human leishmaniasis: where do we stand and what is still missing

P Cecílio, F Oliveira… - Leishmaniases as re …, 2018 - books.google.com
Responsible for up to 30,000 deaths annually, leishmaniasis is a complex spectrum of
diseases endemic in 97 countries around the globe. Disease control relies heavily on the …

Development of nano-carriers for Leishmania vaccine delivery

A Askarizadeh, A Badiee… - Expert Opinion on Drug …, 2020 - Taylor & Francis
Introduction: Leishmaniasis is a neglected tropical infection caused by several species of
intracellular protozoan parasites of the genus Leishmania. It is strongly believed that the …

Designing of a new multi-epitope vaccine against Leishmania major using Leish-F1 epitopes: An In-silico study

M Rabienia, N Mortazavidehkordi, Z Roudbari… - Plos one, 2024 - journals.plos.org
Cutaneous leishmaniasis (CL) is the most common form of the disease which can cause
malignant lesions on the skin. Vaccination for the prevention and treatment of leishmaniasis …