Clonal haematopoiesis (CH) is a common, age-related expansion of blood cells with
somatic mutations that is associated with an increased risk of haematological malignancies …

T-cell acute lymphoblastic leukaemia (T-ALL) is induced by the transformation of T-cell
progenitors and mainly occurs in children and adolescents. Although treatment outcome in …

With the introduction of large-scale molecular profiling methods and high-throughput
sequencing technologies, the genomic features of most lymphoid neoplasms have been …

The TCL1 gene at 14q32. 1 is involved in chromosomal translocations and inversions in
mature T cell leukemias. These leukemias are classified either as T prolymphocytic …

Immune cell-specific expression is one indication of the importance of a gene's role in the
immune response. We have compiled a compendium of microarray expression data for …

The comprehensive genetic alterations underlying the pathogenesis of T-cell prolymphocytic
leukemia (T-PLL) are unknown. To address this, we performed whole-genome sequencing …

Mosaic loss of chromosome Y (mLOY) leading to gonosomal XY/XO commonly occurs
during aging, particularly in smokers. We investigated whether mLOY was associated with …

Human T cell prolymphocytic leukemia can result from chromosomal translocations
involving 14q32. 1 or Xq28 regions. The regions encode a family of protooncogenes (TCL1 …

The TCL1 oncogene at 14q32. 1 is involved in the development of human mature T-cell
leukemia. The mechanism of action of Tcl1 is unknown. Because the virus containing the v …

Structural variation (SV), involving deletions, duplications, inversions and translocations of
DNA segments, is a major source of genetic variability in somatic cells and can dysregulate …