Renal fibrosis is the final pathological process common to any ongoing, chronic kidney
injury or maladaptive repair. It is considered as the underlying pathological process of …

Kidney fibrosis is the common histological end-point of progressive, chronic kidney diseases
(CKDs) regardless of the underlying etiology. The hallmark of renal fibrosis, similar to all …

The glomerular basement membrane (GBM) is a key component of the glomerular capillary
wall and is essential for kidney filtration. The major components of the GBM include …

Chronic kidney disease (CKD) is a long-term condition in which the kidneys do not work
correctly. It has a high prevalence and represents a serious hazard to human health and …

The discoidin domain receptors, DDR1 and DDR2, are nonintegrin collagen receptors that
are members of the receptor tyrosine kinase family. Both DDRs bind a number of different …

Almost all human cancers display dysregulated expression and/or function of one or more
receptor tyrosine kinases (RTKs). The strong causative association between altered RTK …

Background Although diabetic kidney disease demonstrates both familial clustering and
single nucleotide polymorphism heritability, the specific genetic factors influencing risk …

Abstract In 1927, Arthur C. Alport first published his description of a triad of symptoms in a
family with hereditary congenital haemorrhagic nephritis, deafness and ocular changes. A …

Collagen, the most abundant protein in animals, is a key component of extracellular
matrices. Not only do collagens provide essential structural support for connective tissues …

Discoidin domain receptor (DDR) is a collagen-activated receptor tyrosine kinase that plays
critical roles in regulating essential cellular processes such as morphogenesis …