The HIV-1/AIDS pandemic continues to spread unabated worldwide, and no vaccine exists
within our grasp. Effective antiretroviral therapy (ART) has been developed, but ART cannot …

Human immunodeficiency virus (HIV) infection remains an important global public health
problem. About 40 million people are infected with HIV, and this infection caused about …

T regulatory cells (Tregs) are a key component of the immune system, which maintain a
delicate balance between overactive responses and immunosuppression. As such, Treg …

CD4+ T-cell depletion is a hallmark of HIV infection, leading to impairment of cellular
immunity and opportunistic infections, but its contribution to SIV/HIV-associated gut …

African green monkeys (AGMs) are natural hosts of SIV whose infection does not progress to
AIDS. Since early events of infection may be critical to pathogenesis in nonnatural hosts, we …

Early initiation of antiretroviral therapy (ART) significantly improves clinical outcomes and
reduces mortality of infants/children living with HIV. However, the ability of infected cells to …

Natural hosts of simian immunodeficiency virus (SIV) avoid AIDS despite lifelong infection.
Here, we examined how this outcome is achieved by comparing a natural SIV host, African …

Unlike HIV infection, SIV infection is generally nonpathogenic in natural hosts, such as
African green monkeys (AGMs), despite life-long high viral replication. Lack of disease …

ABSTRACT The coronavirus disease 2019 (COVID-19) pandemic has highlighted the need
for safe and effective vaccines to be rapidly developed and distributed worldwide, especially …

Viruses that persist despite seemingly effective antiretroviral treatment (ART) and can
reinitiate infection if treatment is stopped preclude definitive treatment of HIV-1 infected …