The timely resolution of wound healing is critical for restoring the skin as a protective barrier.
The switch from a proinflammatory to a reparative microenvironment must be tightly …

The skin provides the primary protection for the body against external injuries and is
essential in the maintenance of general homeostasis. During ageing, resident cells become …

INTRODUCTION Fibroblasts produce extracellular matrix (ECM) molecules that regulate
tissue strength and resilience. Imbalanced ECM maintenance leads to tissue dysfunction …

Plants are rich sources of a diverse range of chemicals, many of which have significant
metabolic activity. One large group of secondary compounds are the phenolics, which act as …

Venous leg ulcers, diabetic foot ulcers, and pressure ulcers are complex chronic wounds
with multifactorial etiologies that are associated with high patient morbidity and mortality …

Wound healing is one of the most complex processes in multicellular organisms, involving
numerous intra-and intercellular signalling pathways in various cell types. It involves …

Aged skin wounds heal poorly, resulting in medical, economic, and social burdens posed by
nonhealing wounds. Age-related defects in repair are associated with reduced …

Aging is a universal biological process that increases the risk of multiple diseases including
cancer. Growing evidence shows that alterations in the genome and epigenome, driven by …

Cancer-associated fibroblasts (CAFs) play a critical role in the coevolution of breast tumor
cells and their microenvironment by modifying cellular compartments and regulating cancer …

An effective healing response is critical to promote and ensure healthy aging. Major
discoveries in both fields—repair and aging—have led to a better understanding of the …