Transition-metal-catalyzed C–H activation has developed a contemporary approach to the
omnipresent area of retrosynthetic disconnection. Scientific researchers have been tempted …

During the past decades, synthetic organic chemistry discovered that directing group
assisted C–H activation is a key tool for the expedient and siteselective construction of C–C …

Transition metal-catalysed functionalizations of inert C–H bonds to construct C–C bonds
represent an ideal route in the synthesis of valuable organic molecules. Fine tuning of …

Differentiating between two highly similar C–H bonds in a given molecule remains a
fundamental challenge in synthetic organic chemistry. Directing group assisted strategies for …

Site selectivity and stereocontrol remain major challenges in C–H bond functionalization
chemistry, especially in linear aliphatic saturated hydrocarbon scaffolds. We report the …

L, X-Type transient directing groups (TDGs) based on a reversible imine linkage have
emerged as broadly useful tools for C–H activation of ketones and free amines. However …

Ready availability, low cost and low toxicity of cobalt salts have redirected the attention of
researchers away from noble metals, such as Pd, Rh, and Ir, towards Co in the field of C–H …

Peptide modifications can unlock a variety of compounds with structural diversity and
abundant biological activity. In nature, peptide modifications, such as functionalisation at the …

We report the first example of Pd (II)-catalyzed γ-C (sp3)–H activation of ketones directed by
a practical 2, 2-dimethyl aminooxyacetic acid auxiliary. 2-Pyridone ligands are identified to …

Transition metal catalyzed C (sp3)–H functionalization is a rapidly growing field. Despite
severe challenges, distal C–H functionalizations of aliphatic molecules by overriding …