The pancreatic islet β cell senses circulating levels of calorigenic nutrients to secrete insulin
according to the needs of the organism. Altered insulin secretion is linked to various …

The “second messenger” archetype cAMP is one of the most important cellular signalling
molecules with central functions including the regulation of insulin and glucagon secretion …

Since the discovery nearly 60 years ago, cAMP is envisioned as one of the most universal
and versatile second messengers. The tremendous feature of cAMP to tightly control highly …

The dysregulation of glucose-inhibited glucagon secretion from the pancreatic islet α-cell is
a critical component of diabetes pathology and metabolic disease. We show a previously …

Insulin secretion from pancreatic β-cells is tightly regulated by glucose and other nutrients,
hormones, and neural factors. The exocytosis of insulin granules is triggered by an elevation …

Pancreatic β-cells secrete insulin in response to fluctuations in blood fuel concentrations, in
particular glucose and fatty acids. However, chronic fuel surfeit can overwhelm the …

Glucagon secreted by pancreatic α-cells is the major hyperglycemic hormone correcting
acute hypoglycaemia (glucose counterregulation). In diabetes the glucagon response to …

OBJECTIVE cAMP is a critical messenger for insulin and glucagon secretion from pancreatic
β-and α-cells, respectively. Dispersed β-cells show cAMP oscillations, but the signaling …

Excessive glucocorticoid exposure has been shown to be deleterious for pancreatic β-cell
function and insulin release. However, glucocorticoids at physiological levels are essential …

The soy phytoestrogen, genistein, induces thymic atrophy when administered to
ovariectomized mice by injection or in the diet. Injected genistein also causes decreased …