A growing number of neurodegenerative diseases have been found to result from the
expansion of an unstable trinucleotide repeat. Over the past 6 years, researchers have …

Currently available therapies for adult onset neurodegenerative diseases provide
symptomatic relief but do not modify disease progression. Here we explore a new …

Expression of misfolded protein in cultured cells frequently leads to the formation of
juxtanuclear inclusions that have been termed 'aggresomes'. Aggresome formation is an …

Spinal and bulbar muscular atrophy (SBMA) is one of eight inherited neurodegenerative
diseases known to be caused by CAG repeat expansion. The expansion results in an …

Spinal bulbar muscular atrophy is a neurodegenerative disorder caused by a polyglutamine
expansion in the androgen receptor (AR). We show in transiently transfected HeLa cells that …

Eight severe inherited neurodegenerative diseases are caused by expansion of glutamine
repeats in the affected proteins. In every case, proteins with repeats of fewer than 38 …

Within the closing decade of the twentieth century, 14 neurological disorders were shown to
result from the expansion of unstable trinucleotide repeats, establishing this once unique …

Huntington's and Kennedy's disease are autosomal dominant neurodegenerative diseases
caused by pathogenic expansion of polyglutamine tracts. Expansion of glutamine repeats …

The inherited neurodegenerative diseases caused by an expanded glutamine repeat share
the pathologic feature of intranuclear aggregates or inclusions (NI). Here in cell-based …

Huntington's disease (HD) is caused by an expanded CAG trinucleotide repeat encoding a
tract of consecutive glutamines near the amino terminus of huntingtin, a large protein of …