Transition state theory teaches that chemically stable mimics of enzymatic transition states
will bind tightly to their cognate enzymes. Kinetic isotope effects combined with …

Ubiquinone and menaquinone are membrane lipid-soluble carriers of electrons that are
essential for cellular respiration. Eukaryotic cells can synthesize ubiquinone but not …

The Chlamydiae phylum exclusively encompasses bacteria sharing a similar obligate
intracellular life cycle. Existing 16S rDNA data support a high diversity within the phylum …

Chlamydia trachomatis is an obligate intracellular human pathogen responsible for the most
prevalent sexually-transmitted infection in the world. For decades C. trachomatis has been …

Members of the Bacillus genus are industrial cell factories due to their capacity to secrete
significant quantities of biomolecules with industrial applications. The Bacillus …

To develop new potential agents against Chlamydia trachomatis among oleanane type
triterpenoids the synthesis, spectral and X-ray analysis as well as antimicrobial screening of …

Background We have previously revealed that omega‐3 polyunsaturated fatty acids can
prevent Helicobacter pylori infection by blocking the futalosine pathway, an alternative route …

Background PM100117 and PM100118 are glycosylated polyketides with remarkable
antitumor activity, which derive from the marine symbiotic actinobacteria Streptomyces …

We aimed to identify narrow-spectrum natural compounds that specifically inhibit an
alternative menaquinone (MK; vitamin K2) biosynthetic pathway (the futalosine pathway) of …

Chlamydia trachomatis, an obligate intracellular bacterium with limited metabolic
capabilities, possesses the futalosine pathway for menaquinone biosynthesis. Futalosine …