With a high sensitivity and specificity, non‐invasive prenatal testing (NIPT) is an
incomparable screening test for fetal aneuploidy. However, the method is rather newly …

The fetal fraction (FF) is a function of both biological factors and bioinformatics algorithms
used to interpret DNA sequencing results. It is an essential quality control component of …

Preeclampsia (PE) is a leading cause for peripartal morbidity, especially if developing early
in gestation. To enable prophylaxis in the prevention of PE, pregnancies at risk of PE must …

Purpose To assess the clinical performance of an expanded noninvasive prenatal screening
(NIPS) test (“NIPS-Plus”) for detection of both aneuploidy and genome-wide microdeletion …

Background Blood-based methods using cell-free DNA (cfDNA) are under development as
an alternative to existing screening tests. However, early-stage detection of cancer using …

Whole-genome sequencing (WGS) of maternal plasma cell-free DNA (cfDNA) can
potentially evaluate all 24 chromosomes to identify abnormalities of the placenta, fetus, or …

Objective Sufficient fetal DNA in a maternal plasma sample is required for accurate
aneuploidy detection via noninvasive prenatal testing, thus highlighting a need to …

Background Current cell-free DNA assessment of fetal chromosomes does not analyze and
report on all chromosomes. Hence, a significant proportion of fetal chromosomal …

This review delves into the rapidly evolving landscape of liquid biopsy technologies based
on cell-free DNA (cfDNA) and cell-free RNA (cfRNA) and their increasingly prominent role in …

Circulating cell-free DNA (cfDNA) has received increasing interest as an apparent
breakthrough approach in diagnostics, personalized medicine, and tumor biology. However …