Myostatin as a biomarker of muscle wasting and other pathologies-state of the art and knowledge gaps

J Baczek, M Silkiewicz, ZB Wojszel - Nutrients, 2020 - mdpi.com
Sarcopenia is a geriatric syndrome with a significant impact on older patients' quality of life,
morbidity and mortality. Despite the new available criteria, its early diagnosis remains …

Myostatin: Basic biology to clinical application

P Esposito, D Picciotto, Y Battaglia, F Costigliolo… - Advances in clinical …, 2022 - Elsevier
Myostatin is a member of the transforming growth factor (TGF)-β superfamily. It is expressed
by animal and human skeletal muscle cells where it limits muscle growth and promotes …

Association between Sarcopenia and Insulin‐Like Growth Factor‐1, Myostatin, and Insulin Resistance in Elderly Patients Undergoing Hemodialysis

N Widajanti, SA Soelistijo, U Hadi… - Journal of aging …, 2022 - Wiley Online Library
Sarcopenia is common in hemodialysis patients, especially in the elderly patients
undergoing hemodialysis. Various factors may contribute to the occurrence of sarcopenia …

Mechanisms of myostatin and activin A accumulation in chronic kidney disease

S Bataille, L Dou, M Bartoli, M Sallée… - Nephrology Dialysis …, 2022 - academic.oup.com
Background Myostatin and activin A induce muscle wasting by activating the ubiquitin
proteasome system and inhibiting the Akt/mammalian target of rapamycin pathway. In …

Ultrasonography of quadriceps femoris muscle and subcutaneous fat tissue and body composition by BIVA in chronic dialysis patients

Y Battaglia, I Ullo, S Massarenti, P Esposito… - Nutrients, 2020 - mdpi.com
Protein Energy Wasting (PEW) in hemodialysis (HD) patients is a multifactorial condition due
to specific pathology-related pathogenetic mechanisms, leading to loss of skeletal muscle …

[HTML][HTML] Adipokines and Myokines as Markers of Malnutrition and Sarcopenia in Patients Receiving Kidney Replacement Therapy: An Observational, Cross-Sectional …

S Czaja-Stolc, A Chatrenet, M Potrykus, J Ruszkowski… - Nutrients, 2024 - mdpi.com
Chronic kidney disease (CKD) is linked to an elevated risk of malnutrition and sarcopenia,
contributing to the intricate network of CKD-related metabolic disorders. Adipokines and …

Pathophysiology of Physical Exercise in Kidney Patients: Unveiling New Players-The Role of Myokines

D Picciotto, L Macciò, D Verzola, F Baciga… - Kidney & Blood …, 2024 - karger.com
Background Chronic kidney disease (CKD) is a progressive systemic condition
characterized by numerous complications. Among these, alterations in skeletal muscle …

The Impact of Physical Exercise on microRNAs in Hemodialysis Patients: A Review and a Protocol for an Ancillary Study

R Elia, G Piva, F Bulighin, N Lamberti, F Manfredini… - Biomedicines, 2024 - mdpi.com
Physical inactivity is considered a significant risk factor for mortality and morbidity among
chronic hemodialysis (HD) patients. Therefore, physical exercise is recommended in the …

Impact of electrical muscle stimulation on serum myostatin level and maintenance of skeletal muscle mass in patients undergoing living‐donor liver transplantation …

Y Tsutsui, S Itoh, T Toshima, S Yoshio… - Hepatology …, 2024 - Wiley Online Library
Aim Sarcopenia is reportedly associated with a poor prognosis in patients who undergo
living‐donor liver transplantation (LDLT), most of whom are not able to tolerate muscle …

Serum myostatin at dialysis initiation may predict 1-year mortality and hospitalization

M Sakashita, Y Hamasaki, R Oki, Y Komaru… - Nephron, 2024 - karger.com
Objective: Myostatin, which is known as a negative skeleton muscle regulator, is associated
with mortality in maintenance hemodialysis patients. However, the significance of serum …