The complex heterogeneity of cells, and their interconnectedness with each other, are major
challenges to identifying clinically relevant measurements that reflect the state and capability …

NK cells eliminate virus-infected and tumor cells by releasing cytotoxic granules containing
granzyme B (GrzB) or by engaging death receptors that initiate caspase cascades. The …

In this Review, we attempt to give an overview of methods developed for chemical analysis
of single cells. This is an important topic for several reasons. Many biological systems have …

Natural Killer (NK) cells can engage multiple virally infected or tumor cells sequentially and
deliver perforin for cytolytic killing of these targets. Using microscopy to visualize …

Tumor cell populations have been recently proposed to be composed of two compartments:
tumor-initiating cells characterized by a slow and asymmetrical growth, and the …

Despite intense scrutiny of the molecular interactions between natural killer (NK) and target
cells, few studies have been devoted to dissection of the basic functional heterogeneity in …

NK cells are cytotoxic lymphocytes important in defense against viral infection and cancer.
NK cells mediate cytotoxicity predominantly through directed secretion of lytic granules …

Most common methods of cellular analysis employ the top-down approach (investigating
proteomics or genomics directly), thereby destroying the cell, which does not allow the …

Inflammation is the typical result of activating the host immune system against pathogens,
and it helps to clear microbes from tissues. However, inflammation can occur in the absence …

Natural killer (NK) cells belong to the innate arm of the immune system and though activated
NK cells can modulate immune responses through the secretion of cytokines, their primary …