Mitochondria adapt to increased energy demands during muscle contraction by acutely
altering metabolite fluxes and substrate oxidation. With age, an impaired mitochondrial …

Deoxy-ATP (dATP), a naturally occurring near analog of ATP, is a well-documented myosin
activator that has been shown to increase contractile force, improve pump function, and …

Transplanted human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) improve
ventricular performance when delivered acutely post-myocardial infarction but are ineffective …

Sarcopenia, the age-related loss of muscle mass and function, contributes to decreased
quality of life in the elderly and increased healthcare costs. Decreased skeletal muscle …

Cystic Fibrosis (CF) is a progressive genetic disease that leads to dysfunction of ion
transport across epithelial cell membranes. A major hallmark in CF is chronic inflammation …

This thesis investigates the impact of physiological and environmental factors on cardiac
health and injury using human cardiac organoids as a model. In this project, a bioreactor …