Covalent organic frameworks (COFs) are porous organic polymeric materials that are
composed of organic elements and linked together by the thermodynamically stable …

T cell activation and function require a structured engagement of antigen-presenting cells.
These cell contacts are characterized by two distinct dynamics in vivo: transient contacts …

Nanosized artificial antigen-presenting cells (aAPCs) with efficient signal presentation hold
great promise for in vivo adoptive cell therapy. Here, we used DNA origami nanostructures …

Active anti-cancer immune responses depend on efficient presentation of tumor antigens
and co-stimulatory signals by antigen-presenting cells (APCs). Therapy with autologous …

Mechanical forces play an increasingly recognized role in modulating cell function. This
report demonstrates mechanosensing by T cells, using polyacrylamide gels presenting …

Mechanical forces have key roles in regulating activation of T cells and coordination of the
adaptive immune response. A recent example is the ability of T cells to sense the rigidity of …

Recent achievements in the field of immunotherapy, such as the development of engineered
T cells used in adoptive cell therapy, are introducing more efficient strategies to combat …

T cells are often referred to as the 'guided missiles' of our immune system because of their
capacity to traffic to and accumulate at sites of infection or disease, destroy infected or …

T cell activation by dendritic cells (DCs) involves forces exerted by the T cell actin
cytoskeleton, which are opposed by the cortical cytoskeleton of the interacting antigen …

Artificial antigen presenting cells (aAPCs) with surface‐anchored T cell activating ligands
hold great potential in adoptive immunotherapy. However, it remains challenging to …