Progress in the Synthesis of Fused 1, 2, 3‐Triazoles

H Kumar, M Dhameja, M Rizvi, P Gupta - ChemistrySelect, 2021 - Wiley Online Library
Fused heterocycles display prodigious prominence in diverse field ranging from medicinal
chemistry to material science and chemical biology to catalysis. Owing to biological …

Fused benzo [1, 3] thiazine-1, 2, 3-triazole hybrids: Microwave-assisted one-pot synthesis, in vitro antibacterial, antibiofilm, and in silico ADME studies

ER Sucharitha, TM Krishna, R Manchal… - Bioorganic & Medicinal …, 2021 - Elsevier
In this paper, we report an efficient one-pot three-component reaction sequences comprising
Cu (I)-catalyzed 1, 3-dipolar cycloaddition (CuAAC) followed by Cu-catalyzed arylation of …

Advancements in transition metal-catalyzed 1, 2, 3-triazole synthesis via azide–alkyne cycloaddition

A Ullah, A Wahab, S Ahmad, S Khan… - Reviews in Inorganic …, 2024 - degruyter.com
triazoles have emerged as important structural motifs in chemical biology, attracting
increasing focus in recent years because of their wide range of uses. These compounds can …

Synthesis of novel pyrido [2, 3-d] pyrimidine-thiazolidine-1, 2, 3-triazoles: Potent EGFR targeting anticancer agents

SR Bandi, R Kapavarapu, R Palabindela… - Journal of Molecular …, 2023 - Elsevier
In this study, we designed and synthesized a number of novel pyrido [2, 3-d] pyrimidine-
thiazolidine-1, 2, 3-triazole derivatives and investigated them in vitro for their inhibitory …

Benzothiazole-[1, 2, 3] triazolo [5, 1-a] isoindoles: Synthesis, anticancer activity, bioavailability and in silico studies against Gama-Tubulin protein

M Kumar, SK Nukala, M Ravinder, TM Krishna… - Journal of Molecular …, 2022 - Elsevier
We, herein, reported the CuI catalyzed synthesis of some novel fused benzothiazole-1, 2, 3-
triazole hybrids (5a-5o) in one-pot. The in vitro anticancer activity of these compounds …

Synthesis and biological evaluation of coumarine-imidazo [1, 2-c][1, 2, 3] triazoles: PEG-400 mediated one-pot reaction under ultrasonic irradiation

R Samala, SK Nukala, R Manchal, VR Nagavelli… - Journal of Molecular …, 2023 - Elsevier
Synthetic chemists have organized easy and effective ways for perfect synthesis in response
to the requirement for scaffolds that are crucial for medical applications. To investigate the …

Synthesis and biological evaluation of novel [1, 2, 3] triazolo-pyrrolo [1, 2-a] pyrido [4, 3-d] pyrimidines as EGFR targeting anticancer agents

SR Bandi, N Kavitha, SK Nukala… - Journal of Molecular …, 2023 - Elsevier
Herein, we synthesized some new fused [1, 2, 3] triazolo-pyrrolo [1, 2-a] pyrido [4, 3-d]
pyrimidines via click chemistry followed by carbon-carbon bond coupling as key approach …

One‐pot synthesis and biological evaluation of novel 4‐[3‐fluoro‐4‐(morpholin‐4‐yl)]phenyl‐1H‐1,2,3‐triazole derivatives as potent antibacterial and anticancer …

S Narsimha, SK Nukala… - Journal of …, 2020 - Wiley Online Library
In search of better antibacterial and anticancer agents, a series of novel 4‐[3‐fluoro‐4‐
(morpholin‐4‐yl)] phenyl‐1 H‐1, 2, 3‐triazole derivatives were synthesized (6a‐l and 8a‐j) …

Design, synthesis and evaluation of novel 1, 2, 4-triazole derivatives as promising anticancer agents

L Emami, S Sadeghian, A Mojaddami, S Khabnadideh… - BMC chemistry, 2022 - Springer
Herein, we reported the synthesis of nineteen novel 1, 2, 4-triazole derivatives including 1, 3-
diphenyl-2-(1H-1, 2, 4-triazol-1-yl) propan-1-ones (7a-e), 1-(1, 3-diphenylpropan-2-yl)-1 H-1 …

Cu(I)‐Catalyzed One‐Pot Synthesis of [1,2,3]Triazolo[5,1‐a] isoquinolin‐6(5H)‐one Derivatives as EGFR‐Targeting Anticancer Agents

R Samala, S Kumar Nukala… - …, 2022 - Wiley Online Library
The CuI promoted one‐pot multi‐component synthesis of new fused [1, 2, 3] triazolo [5, 1‐a]
isoquinoline derivatives (4 a–4 h, 8 a–8 f & 9 a–9 f) without isolating unsafe azides and their …