A bioartificial endocrine pancreas is proposed as a future alternative to current treatment
options. Patients with insulin-secretion deficiency might benefit. This is the first systematic …

Human allogeneic islet transplantation (ITx) is emerging as a promising treatment option for
qualified patients with type 1 diabetes. However, widespread clinical application of …

The concept of gap junctions and their role in intercellular communication has been known
for around 50 years. Considerable progress has been made in understanding the …

Abstract Connexin 43 (Cx43) is the most ubiquitous connexin in various cells, and presents
as hemichannels (HCs) and gap junctions (GJs) on the cell membrane. We have recently …

Vascularization remains a substantial limitation to the viability of engineered tissue. By
comparing in vivo vascularization dynamics of a self-assembled prevascular endothelial …

Kidney transplantation is now a mainstream therapy for end-stage renal disease. However,
with approximately 96,000 people on the waiting list and only one-fourth of these patients …

Despite a strong clinical demand for tissue replacement therapies, few tissue-engineered
constructs (TECs) have attained FDA approval. Fewer still demonstrate long term viability of …

Wound healing in human oral mucosal gingiva is faster and results in significantly reduced
scar formation as compared to similar skin wounds. Fibroblasts are the most abundant group …