Hailey–Hailey disease is a rare blistering dermatosis first described in 1939 by the brothers
Howard and Hugh Hailey. Its incidence is estimated at 1/50,000. The inheritance is …

Acantholytic skin disorders, by definition, compromise intercellular adhesion between
epidermal keratinocytes. The root cause of blistering in these diseases traces back to direct …

The essential biometal manganese (Mn) serves as a cofactor for several enzymes that are
crucial for the prevention of human diseases. Whether intracellular Mn levels may be sensed …

Transcription–blocking lesions are specifically targeted by transcription-coupled nucleotide
excision repair (TC-NER), which prevents DNA damage-induced cellular toxicity and …

DNA is an entity shielded by mechanisms that maintain genomic stability and are essential
for living cells; however, DNA is constantly subject to assaults from the environment …

Understanding which intracellular signaling pathways are activated by manganese stress is
crucial to decipher how metal overload compromise cellular integrity. Here, we unveil a role …

Hailey-Hailey disease is an autosomal genetic disease caused by mutations in one of the
two ATP2C 1 alleles encoding the secretory pathway Ca2+/Mn2+-ATPase, hSPCA1. The …

This report presents two cases of patients with long-standing, treatment-resistant Hailey-
Hailey disease (HHD) who experienced significant symptom relief through a combination …

The essential biometal manganese (Mn) serves as a cofactor for several enzymes that are
crucial for the prevention of human diseases. Whether intracellular Mn levels may be sensed …

Hailey‐Hailey disease (HHD) is a rare autosomal dominantly inherited disorder caused by
mutations in the ATP2C1 gene that encodes an adenosine triphosphate (ATP)‐powered …