Structural mapping of Nav1.7 antagonists
Voltage-gated sodium (Nav) channels are targeted by a number of widely used and
investigational drugs for the treatment of epilepsy, arrhythmia, pain, and other disorders …
investigational drugs for the treatment of epilepsy, arrhythmia, pain, and other disorders …
Inhibition of Na V 1.7: the possibility of ideal analgesics
Y Kitano, T Shinozuka - RSC Medicinal Chemistry, 2022 - pubs.rsc.org
The selective inhibition of NaV1. 7 is a promising strategy for developing novel analgesic
agents with fewer adverse effects. Although the potent selective inhibition of NaV1. 7 has …
agents with fewer adverse effects. Although the potent selective inhibition of NaV1. 7 has …
A Review of Recent Pharmacological Advances in the Management of Diabetes-Associated Peripheral Neuropathy
O Syed, P Jancic, NN Knezevic - Pharmaceuticals, 2023 - mdpi.com
Diabetic peripheral neuropathy is a common complication of longstanding diabetes mellitus.
These neuropathies can present in various forms, and with the increasing prevalence of …
These neuropathies can present in various forms, and with the increasing prevalence of …
Reversal of Peripheral Neuropathic Pain by the Small-Molecule Natural Product Narirutin via Block of Nav1.7 Voltage-Gated Sodium Channel
H Yang, Z Shan, W Guo, Y Wang, S Cai, F Li… - International Journal of …, 2022 - mdpi.com
Neuropathic pain is a refractory chronic disease affecting millions of people worldwide.
Given that present painkillers have poor efficacy or severe side effects, developing novel …
Given that present painkillers have poor efficacy or severe side effects, developing novel …
Voltage-gated calcium channels (CaV) in GtoPdb v.2023.1
WA Catterall, E Perez-Reyes, TP Snutch… - IUPHAR/BPS Guide …, 2023 - journals.ed.ac.uk
Ca 2+ channels are voltage-gated ion channels present in the membrane of most excitable
cells. The nomenclature for Ca 2+ channels was proposed by [131] and approved by the NC …
cells. The nomenclature for Ca 2+ channels was proposed by [131] and approved by the NC …
Lacosamide Inhibition of NaV1.7 Channels Depends on its Interaction With the Voltage Sensor Domain and the Channel Pore
JIR Labau, M Alsaloum, M Estacion… - Frontiers in …, 2021 - frontiersin.org
Lacosamide, developed as an anti-epileptic drug, has been used for the treatment of pain.
Unlike typical anticonvulsants and local anesthetics which enhance fast-inactivation and …
Unlike typical anticonvulsants and local anesthetics which enhance fast-inactivation and …
Development of long-acting local anesthetics: a long way from basic research to clinical application
Y Oda - Journal of Anesthesia, 2024 - Springer
Management of postoperative pain remains one of the most challenging aims of modern
anesthesia. Opioids have been the mainstay of postoperative pain management for …
anesthesia. Opioids have been the mainstay of postoperative pain management for …
Voltage-gated sodium channels (NaV) in GtoPdb v.2021.3
WA Catterall, AL Goldin… - IUPHAR/BPS Guide to …, 2021 - journals.ed.ac.uk
Sodium channels are voltage-gated sodium-selective ion channels present in the
membrane of most excitable cells. Sodium channels comprise of one pore-forming α …
membrane of most excitable cells. Sodium channels comprise of one pore-forming α …
High-Throughput Screening of Candidate Analgesics Using a Patient-Derived Human iPSC Model of Nociception Identifies Putative pain reducing compounds
J Thornton, A Capurro, T Henderson… - ESS Open Archive …, 2024 - authorea.com
Background and purpose: In this study, we applied an induced pluripotent stem cell (iPSC)-
based model of inherited erythromelalgia (IEM) to screen a library of 295 small molecules …
based model of inherited erythromelalgia (IEM) to screen a library of 295 small molecules …
RSC Medicinal Chemistry
Y Kitano, T Shinozuka - 2022 - pubs.rsc.org
RSC Medicinal Chemistry Page 1 rsc.li/medchem RSC Medicinal Chemistry ISSN 2632-8682
Volume 13 Number 8 August 2022 Pages 887–1000 REVIEW ARTICLE Yutaka Kitano and …
Volume 13 Number 8 August 2022 Pages 887–1000 REVIEW ARTICLE Yutaka Kitano and …