Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

Intrarenal autoregulatory mechanisms maintain renal blood flow (RBF) and glomerular
filtration rate (GFR) independent of renal perfusion pressure (RPP) over a defined range (80 …

The transient receptor potential vallinoid type 4 (TRPV4) channel has been implicated in the
endothelial shear response and flow-mediated dilation, although the precise functions of this …

Agonist-induced Ca2+ entry is important for the synthesis and release of vasoactive factors
in endothelial cells. The transient receptor potential vanilloid type 4 (TRPV4) channel, a …

In human coronary arterioles (HCAs) from patients with coronary artery disease, flow-
induced dilation is mediated by a unique mechanism involving the release of H2O2 from the …

Background and purpose: Reduction of intracellular calcium ([Ca2+] i) in smooth muscle
cells (SMCs) is an important mechanism by which nitric oxide (NO) dilates blood vessels …

In smooth muscle, Ca2+ controls diverse activities including cell division, contraction and
cell death. Of particular significance in enabling Ca2+ to perform these multiple functions is …

Cyclic ADP‐ribose (cADPR) induces intracellular Ca2+ ([Ca2+] i) release in airway smooth
muscle, and the cADPR antagonist, 8‐amino‐cADPR, abolishes [Ca2+] i oscillations elicited …

In rats, spreading depolarization induces vasodilation/hyperemia in naïve tissue but the
inverse response when artificial cerebrospinal fluid is topically applied to the brain …

The present study was designed to determine the production of nicotinic acid adenine
dinucleotide phosphate (NAADP) and its role associated with lysosomes in mediating …