Primordial follicles are the starting point of follicular development and the basic functional
unit of female reproduction. Primordial follicles are formed around birth, and most of the …

The mammalian ovary has two main functions—producing mature oocytes for fertilization
and secreting hormones for maintaining the ovarian endocrine functions. Both functions are …

Primordial follicle activation is fundamental for folliculogenesis and for the maintenance of
fertility. An effective therapeutic strategy for patients with premature ovarian insufficiency …

Primordial follicle pool established perinatally is a non-renewable resource which
determines the female fecundity in mammals. While the majority of primordial follicles in the …

Simple Summary The PI3K/AKT signaling pathway plays critical roles in regulating a series
of cellular changes to promote tumor development and progression. The cytoskeletal …

Mammalian ovaries consist of follicles as basic functional units. Each follicle comprised an
innermost oocyte and several surrounding flattened granulosa cells. Unlike males …

In female mammals, the majority of primordial follicles (PFs) are physiologically quiescent,
and only a few of them are activated and enter the growing follicle pool. Specific molecules …

In the mammalian ovaries, dormant primordial follicles represent the reproductive reserve of
individual females. Recently, stimulating the activation of primordial follicles in vitro has …

A better understanding of the mechanism of primordial follicle activation will help us better
understand the causes of premature ovarian insufficiency (POI), and will help us identify new …

The list of long non-coding RNAs (lncRNAs) that participate in the function of ovarian
granulosa cells (GCs) is rapidly expanding, but the mechanisms through which lncRNAs …