Glycans as key checkpoints of T cell activity and function

MS Pereira, I Alves, M Vicente, A Campar… - Frontiers in …, 2018 - frontiersin.org
The immune system is highly controlled and fine-tuned by glycosylation, through the
addition of a diversity of carbohydrates structures (glycans) to virtually all immune cell …

[HTML][HTML] Protein glycosylation as a diagnostic and prognostic marker of chronic inflammatory gastrointestinal and liver diseases

X Verhelst, AM Dias, JF Colombel, S Vermeire… - Gastroenterology, 2020 - Elsevier
Glycans are sequences of carbohydrates that are added to proteins or lipids to modulate
their structure and function. Glycans modify proteins required for regulation of immune cells …

Serum biomarkers identify patients who will develop inflammatory bowel diseases up to 5 years before diagnosis

J Torres, F Petralia, T Sato, P Wang, SE Telesco… - Gastroenterology, 2020 - Elsevier
Background & Aims Biomarkers are needed to identify patients at risk for development of
inflammatory bowel diseases. We aimed to identify serum biomarkers of Crohn's disease …

Longitudinal multi-omics analyses of the gut–liver axis reveals metabolic dysregulation in hepatitis C infection and cirrhosis

RO Ali, GM Quinn, R Umarova, JA Haddad… - Nature …, 2023 - nature.com
The gut and liver are connected via the portal vein, and this relationship, which includes the
gut microbiome, is described as the gut–liver axis. Hepatitis C virus (HCV) can infect the liver …

The Hitchhiker's guide to glycoproteomics

T Oliveira, M Thaysen-Andersen… - Biochemical Society …, 2021 - portlandpress.com
Protein glycosylation is one of the most common post-translational modifications that are
essential for cell function across all domains of life. Changes in glycosylation are considered …

Neutralizing anti-granulocyte macrophage-colony stimulating factor autoantibodies recognize post-translational glycosylations on granulocyte macrophage-colony …

A Mortha, R Remark, DM Del Valle, LS Chuang, Z Chai… - Gastroenterology, 2022 - Elsevier
Background & Aims Anti-granulocyte macrophage-colony stimulating factor autoantibodies
(aGMAbs) are detected in patients with ileal Crohn's disease (CD). Their induction and …

Glycans as a key factor in self and nonself discrimination: impact on the breach of immune tolerance

I Alves, Â Fernandes, B Santos‐Pereira… - FEBS …, 2022 - Wiley Online Library
Glycans are carbohydrates that are made by all organisms and covalently conjugated to
other biomolecules. Glycans cover the surface of both human cells and pathogens and are …

Human gut metagenomes encode diverse GH156 sialidases

E Mann, S Shekarriz, MG Surette - Applied and Environmental …, 2022 - Am Soc Microbiol
The intestinal lining is protected by a mucous barrier composed predominantly of complex
carbohydrates. Gut microbes employ diverse glycoside hydrolases (GHs) to liberate …

Application of omics beyond the central dogma in coronary heart disease research: A bibliometric study and literature review

SY Lim, S Selvaraji, H Lau, SFY Li - Computers in biology and medicine, 2022 - Elsevier
Despite remarkable progress in disease diagnosis and treatment, coronary heart disease
(CHD) remains the number one leading cause of death worldwide. Many practical …

Infant growth, neurodevelopment and gut microbiota during infancy: which nutrients are crucial?

T Cerdó, E Diéguez, C Campoy - Current Opinion in Clinical …, 2019 - journals.lww.com
Infant growth, neurodevelopment and gut microbiota during in... : Current Opinion in Clinical
Nutrition & Metabolic Care Infant growth, neurodevelopment and gut microbiota during …