The multifaceted ATPase inhibitory factor 1 (IF1) in energy metabolism reprogramming and mitochondrial dysfunction: a new player in age-associated disorders?
E Gore, T Duparc, A Genoux, B Perret… - Antioxidants & Redox …, 2022 - liebertpub.com
Significance: The mitochondrial oxidative phosphorylation (OXPHOS) system, comprising
the electron transport chain and ATP synthase, generates membrane potential, drives ATP …
the electron transport chain and ATP synthase, generates membrane potential, drives ATP …
Are alterations in skeletal muscle mitochondria a cause or consequence of insulin resistance?
As a major site of glucose uptake following a meal, skeletal muscle has an important role in
whole-body glucose metabolism. Evidence in humans and animal models of insulin …
whole-body glucose metabolism. Evidence in humans and animal models of insulin …
IF1 ablation prevents ATP synthase oligomerization, enhances mitochondrial ATP turnover and promotes an adenosine-mediated pro-inflammatory phenotype
S Domínguez-Zorita, I Romero-Carramiñana… - Cell Death & …, 2023 - nature.com
Abstract ATPase Inhibitory Factor 1 (IF1) regulates the activity of mitochondrial ATP
synthase. The expression of IF1 in differentiated human and mouse cells is highly variable …
synthase. The expression of IF1 in differentiated human and mouse cells is highly variable …
Molecular pathways behind acquired obesity: Adipose tissue and skeletal muscle multiomics in monozygotic twin pairs discordant for BMI
BW van der Kolk, S Saari, A Lovric, M Arif… - Cell Reports …, 2021 - cell.com
Tissue-specific mechanisms prompting obesity-related development complications in
humans remain unclear. We apply multiomics analyses of subcutaneous adipose tissue and …
humans remain unclear. We apply multiomics analyses of subcutaneous adipose tissue and …
IF1 is a cold-regulated switch of ATP synthase hydrolytic activity to support thermogenesis in brown fat
HS Brunetta, AS Jung, F Valdivieso-Rivera… - The EMBO …, 2024 - embopress.org
While mechanisms controlling uncoupling protein-1 (UCP1) in thermogenic adipocytes play
a pivotal role in non-shivering thermogenesis, it remains unclear whether F1Fo-ATP …
a pivotal role in non-shivering thermogenesis, it remains unclear whether F1Fo-ATP …
Dysfunctional oxidative phosphorylation shunts branched‐chain amino acid catabolism onto lipogenesis in skeletal muscle
C Sánchez‐González, C Nuevo‐Tapioles… - The EMBO …, 2020 - embopress.org
It is controversial whether mitochondrial dysfunction in skeletal muscle is the cause or
consequence of metabolic disorders. Herein, we demonstrate that in vivo inhibition of …
consequence of metabolic disorders. Herein, we demonstrate that in vivo inhibition of …
Manipulation of the miR-378a/mt-ATP6 regulatory axis rescues ATP synthase in the diabetic heart and offers a novel role for lncRNA Kcnq1ot1
AJ Durr, QA Hathaway, A Kunovac… - … of Physiology-Cell …, 2022 - journals.physiology.org
Diabetes mellitus has been linked to an increase in mitochondrial microRNA-378a (miR-
378a) content. Enhanced miR-378a content has been associated with a reduction in …
378a) content. Enhanced miR-378a content has been associated with a reduction in …
Exploring protein relative relations in skeletal muscle proteomic analysis for insights into insulin resistance and type 2 diabetes
A Czajkowska, M Czajkowski, L Szczerbinski… - Scientific Reports, 2024 - nature.com
The escalating prevalence of insulin resistance (IR) and type 2 diabetes mellitus (T2D)
underscores the urgent need for improved early detection techniques and effective treatment …
underscores the urgent need for improved early detection techniques and effective treatment …
Skeletal muscle proteomes reveal downregulation of mitochondrial proteins in transition from prediabetes into type 2 diabetes
Skeletal muscle insulin resistance is a central defect in the pathogenesis of type 2 diabetes
(T2D). Here, we analyzed skeletal muscle proteome in 148 vastus lateralis muscle biopsies …
(T2D). Here, we analyzed skeletal muscle proteome in 148 vastus lateralis muscle biopsies …
Alginate oligosaccharide (AOS) improves immuno-metabolic systems by inhibiting STOML2 overexpression in high-fat-diet-induced obese zebrafish
VC Tran, SY Cho, J Kwon, D Kim - Food & function, 2019 - pubs.rsc.org
This study aimed to evaluate the potentially beneficial effects of alginate oligosaccharide
(AOS) on the modulation of immuno-metabolic pathways in high-fat-diet (HFD)-induced …
(AOS) on the modulation of immuno-metabolic pathways in high-fat-diet (HFD)-induced …