Fluorescent probes for bioimaging of potential biomarkers in Parkinson's disease
Parkinson's disease (PD), as the second most common neurodegenerative disease, is
caused by complex pathological processes and currently remains very difficult to treat. PD …
caused by complex pathological processes and currently remains very difficult to treat. PD …
Ligands of adrenergic receptors: a structural point of view
Y Wu, L Zeng, S Zhao - Biomolecules, 2021 - mdpi.com
Adrenergic receptors are G protein-coupled receptors for epinephrine and norepinephrine.
They are targets of many drugs for various conditions, including treatment of hypertension …
They are targets of many drugs for various conditions, including treatment of hypertension …
Structures of the entire human opioid receptor family
Opioids are effective analgesics, but their use is beset by serious side effects, including
addiction and respiratory depression, which contribute to the ongoing opioid crisis. The …
addiction and respiratory depression, which contribute to the ongoing opioid crisis. The …
Structures of the 5-HT2A receptor in complex with the antipsychotics risperidone and zotepine
Many drugs target the serotonin 2A receptor (5-HT2AR), including second-generation
antipsychotics that also target the dopamine D2 receptor (D2R). These drugs often produce …
antipsychotics that also target the dopamine D2 receptor (D2R). These drugs often produce …
Structural and signaling mechanisms of TAAR1 enabled preferential agonist design
P Shang, N Rong, JJ Jiang, J Cheng, MH Zhang… - Cell, 2023 - cell.com
Trace amine-associated receptor 1 (TAAR1) senses a spectrum of endogenous amine-
containing metabolites (EAMs) to mediate diverse psychological functions and is useful for …
containing metabolites (EAMs) to mediate diverse psychological functions and is useful for …
New paradigms in GPCR drug discovery
KA Jacobson - Biochemical pharmacology, 2015 - Elsevier
G protein-coupled receptors (GPCRs) remain a major domain of pharmaceutical discovery.
The identification of GPCR lead compounds and their optimization are now structure-based …
The identification of GPCR lead compounds and their optimization are now structure-based …
Structural insights into the agonists binding and receptor selectivity of human histamine H4 receptor
D Im, J Kishikawa, Y Shiimura, H Hisano, A Ito… - Nature …, 2023 - nature.com
Histamine is a biogenic amine that participates in allergic and inflammatory processes by
stimulating histamine receptors. The histamine H4 receptor (H4R) is a potential therapeutic …
stimulating histamine receptors. The histamine H4 receptor (H4R) is a potential therapeutic …
Haloperidol bound D2 dopamine receptor structure inspired the discovery of subtype selective ligands
The D2 dopamine receptor (DRD2) is one of the most well-established therapeutic targets
for neuropsychiatric and endocrine disorders. Most clinically approved and investigational …
for neuropsychiatric and endocrine disorders. Most clinically approved and investigational …
Structure of the dopamine D2 receptor in complex with the antipsychotic drug spiperone
In addition to the serotonin 5-HT2A receptor (5-HT2AR), the dopamine D2 receptor (D2R) is
a key therapeutic target of antipsychotics for the treatment of schizophrenia. The inactive …
a key therapeutic target of antipsychotics for the treatment of schizophrenia. The inactive …
Structural basis for recognition of antihistamine drug by human histamine receptor
X Peng, L Yang, Z Liu, S Lou, S Mei, M Li… - Nature …, 2022 - nature.com
The histamine receptors belong to the G protein-coupled receptor (GPCR) superfamily, and
play important roles in the regulation of histamine and other neurotransmitters in the central …
play important roles in the regulation of histamine and other neurotransmitters in the central …