The β-lactams are the most widely used antibacterial agents worldwide. These antibiotics, a
group that includes the penicillins and cephalosporins, are covalent inhibitors that target …

Serine/metallo-carbapenemase-coproducing pathogens, often referred to as “superbugs”,
are a significant clinical problem. They hydrolyze nearly all available β-lactam antibiotics …

Metallo-β-lactamases (MBLs) are zinc-dependent enzymes capable of hydrolyzing all
bicyclic β-lactam antibiotics, posing a great threat to public health. However, there are …

Addressing antibacterial resistance is a major concern of the modern world. The
development of new approaches to meet this deadly threat is a critical priority. In this article …

Some antibiotics that are frequently employed are β-lactams. In light of the hydrolytic
process of β-lactamase, found in Gram-negative bacteria, inhibitors of β-lactamase (BLIs) …

The discovery of β-lactam (BL) antibiotics in the early 20th century represented a remarkable
advancement in human medicine, allowing for the widespread treatment of infectious …

L1 is a dizinc subclass B3 metallo-β-lactamase (MBL) that hydrolyzes most β-lactam
antibiotics and is a key resistance determinant in the Gram-negative pathogen …

β-lactams are the most prescribed class of antibiotics due to their potent, broad-spectrum
antimicrobial activities. However, alarming rates of antimicrobial resistance now threaten the …

Antimicrobial resistance is a global public health threat. Metallo-β-lactamases (MBLs)
inactivate β-lactam antibiotics, including carbapenems, are disseminating among Gram …

Cefiderocol is the first approved catechol-conjugated cephalosporin against multidrug-
resistant Gram-negative bacteria, while its application was limited by poor chemical stability …