Although axonal loss has been observed in demyelinated multiple sclerosis (MS) lesions,
there has been a major focus on understanding mechanisms of demyelination. However …

We do not have currently satisfactory clinical and anatomical correlates to gauge disability in
multiple sclerosis. Structural biomarkers (such as MRI) are hindered because they cannot …

There has been growing interest in the use of retinal imaging for tracking disease
progression in multiple sclerosis. However, systematic and detailed pathological …

The role of the PYHIN family member absent in melanoma 2 (AIM2), another important
inflammasome sensor, in EAE remains unclear. In this study, we found that AIM2 negatively …

Objective We set out to assess the dynamics of retinal injury after acute optic neuritis (ON)
and their association with clinical visual outcomes. Methods Thirty‐one consecutive patients …

The tryptophan (trp)‐catabolizing enzyme indolamine 2, 3‐dioxygenase (IDO) is induced by
the T helper 1 (Th 1) cytokine IFN‐γ during infections in various tissues including the brain …

Background: Neuronal loss in multiple sclerosis (MS) and its animal model, experimental
autoimmune encephalomyelitis (EAE), correlates with permanent neurological dysfunction …

Murine models of experimental autoimmune encephalomyelitis (EAE) are important vehicles
for studying the effects of genetic manipulation on disease processes related to multiple …

In the current study, the feasibility and reproducibility of in vivo diffusion tensor imaging (DTI)
of the spinal cord in normal mice are illustrated followed by its application to mice with …

It has been previously demonstrated that 17β-estradiol (E2) inhibits the response of
microglia, the resident brain macrophages, to acute injuries in specific brain regions. We …