Thermogenesis is one of the most important homeostatic mechanisms that evolved during
vertebrate evolution. Despite its importance for the survival of the organism, the mechanistic …

Mammalian genome is pervasively transcribed, producing large number of noncoding RNAs
(ncRNAs), including long noncoding RNAs (lncRNAs), primary miRNAs (pri-miRNA), and …

Mitochondria undergo fragmentation in response to electron transport chain (ETC) poisons
and mitochondrial DNA–linked disease mutations, yet how these stimuli mechanistically …

Muscle contraction depends on release of Ca2+ from the sarcoplasmic reticulum (SR) and
reuptake by the Ca2+ adenosine triphosphatase SERCA. We discovered a putative muscle …

Functional micropeptides can be concealed within RNAs that appear to be noncoding. We
discovered a conserved micropeptide, which we named myoregulin (MLN), encoded by a …

The role of skeletal muscle in nonshivering thermogenesis (NST) is not well understood.
Here we show that sarcolipin (Sln), a newly identified regulator of the sarco/endoplasmic …

P-type ATPases are ATP-powered ion pumps that establish ion concentration gradients
across biological membranes, and are distinct from other ATPases in that the reaction cycle …

Exercise can rapidly increase core body temperature, and research has indicated that
elevated internal body temperature can independently contribute to fatigue during physical …

The major objective of this study was to understand the molecular basis of how sarcolipin
uncoupling of SERCA regulates muscle oxidative metabolism. Using genetically engineered …

Sarcolipin (SLN) is a novel regulator of sarcoplasmic reticulum Ca 2+ ATPase (SERCA) in
muscle. SLN binding to SERCA uncouples Ca 2+ transport from ATP hydrolysis. By this …