The effects of aging in the hippocampus and cognitive decline
Aging is a natural process that is associated with cognitive decline as well as functional and
social impairments. One structure of particular interest when considering aging and …
social impairments. One structure of particular interest when considering aging and …
SIRT1 in neurodevelopment and brain senescence
AZ Herskovits, L Guarente - Neuron, 2014 - cell.com
Sirtuins are nicotinamide adenine dinucleotide (NAD+)-dependent deacylases that have
traditionally been linked with calorie restriction and aging in mammals. These proteins also …
traditionally been linked with calorie restriction and aging in mammals. These proteins also …
Neuroinflammation and neurogenesis in Alzheimer's disease and potential therapeutic approaches
In adult brain, new neurons are generated throughout adulthood in the subventricular zone
and the dentate gyrus; this process is commonly known as adult neurogenesis. The …
and the dentate gyrus; this process is commonly known as adult neurogenesis. The …
Hippocampal sirtuin 1 signaling mediates depression-like behavior
N Abe-Higuchi, S Uchida, H Yamagata, F Higuchi… - Biological …, 2016 - Elsevier
Background Although depression is the leading cause of disability worldwide, its
pathophysiology is poorly understood. Recent evidence has suggested that sirtuins (SIRTs) …
pathophysiology is poorly understood. Recent evidence has suggested that sirtuins (SIRTs) …
[HTML][HTML] Electroacupuncture ameliorates cerebral ischemia/reperfusion injury by suppressing autophagy via the SIRT1-FOXO1 signaling pathway
ZG Mei, YG Huang, ZT Feng, YN Luo, SB Yang… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Cerebral ischemia/reperfusion (CIR) injury occurs when blood flow is restored in the brain,
causing secondary damage to the ischemic tissues. Previous studies have shown that …
causing secondary damage to the ischemic tissues. Previous studies have shown that …
SIRT1 in the brain—connections with aging-associated disorders and lifespan
F Ng, L Wijaya, BL Tang - Frontiers in cellular neuroscience, 2015 - frontiersin.org
The silent mating type information regulation 2 proteins (sirtuins) 1 of class III histone
deacetylases (HDACs) have been associated with health span and longevity. SIRT1, the …
deacetylases (HDACs) have been associated with health span and longevity. SIRT1, the …
Sirtuins in neuroendocrine regulation and neurological diseases
Y Fujita, T Yamashita - Frontiers in neuroscience, 2018 - frontiersin.org
Silent information regulator 1 (SIRT1) is a mammalian homolog of the nicotinamide adenine
dinucleotide (NAD)-dependent deacetylase sirtuin family. Sirtuin was originally studied as …
dinucleotide (NAD)-dependent deacetylase sirtuin family. Sirtuin was originally studied as …
Activation of SIRT1 ameliorates LPS-induced lung injury in mice via decreasing endothelial tight junction permeability
C Fu, S Hao, X Xu, J Zhou, Z Liu, H Lu… - Acta Pharmacologica …, 2019 - nature.com
The integrity of the endothelial barrier is a determinant of the prognosis of
lipopolysaccharide (LPS)-induced acute lung injury (ALI). In this study, we investigated …
lipopolysaccharide (LPS)-induced acute lung injury (ALI). In this study, we investigated …
SIRT1 promotes neuronal fortification in neurodegenerative diseases through attenuation of pathological hallmarks and enhancement of cellular lifespan
Neurodegeneration is a complex neurological phenomenon characterized by disturbed
coherence in neuronal efflux. Progressive neuronal loss and brain damage due to various …
coherence in neuronal efflux. Progressive neuronal loss and brain damage due to various …
The promise and perils of HDAC inhibitors in neurodegeneration
A Didonna, P Opal - Annals of clinical and translational …, 2015 - Wiley Online Library
Histone deacetylases (HDAC s) represent emerging therapeutic targets in the context of
neurodegeneration. Indeed, pharmacologic inhibition of HDAC s activity in the nervous …
neurodegeneration. Indeed, pharmacologic inhibition of HDAC s activity in the nervous …