Successful progression from bench to bedside for regenerative medicine products is
challenging and requires a multidisciplinary approach. What has not yet been fully …

Permanent fibrosis and chronic deterioration of heart function in patients after myocardial
infarction present a major health-care burden worldwide. In contrast to the restricted …

Repairing injured tissues/organs is one of the major challenges for the maintenance of
proper organ function in adulthood. In mammals, the central nervous system including the …

Large-scale regeneration in the adult central nervous system is a unique capacity of
salamanders among tetrapods. Salamanders can replace neuronal populations, repair …

The axonal growth‐restrictive character of traumatic spinal cord injury (SCI) makes finding a
therapeutic strategy a very demanding task, due to the postinjury events impeditive to …

Axolotls are uniquely able to resolve spinal cord injuries, but little is known about the
mechanisms underlying spinal cord regeneration. We previously found that tail amputation …

Background The axolotl is a key model to study appendicular regeneration. The limb
complexity resembles that of humans in structure and tissue components; however, axolotl …

Visualizing, tracking and reconstructing cell lineages in developing embryos has been an
ongoing effort for well over a century. Recent advances in light microscopy, labelling …

The salamander Ambystoma mexicanum, commonly called “the axolotl” has a long,
illustrious history as a model organism, perhaps with one of the longest track records as a …

In the developing nervous system, neural stem cells are polarized and maintain an apical
domain facing a central lumen. The presence of apical membrane is thought to have a …