A relapsing-remitting course is very common in patients with an Alcohol Use Disorder
(AUD). Understanding the determinants associated with alcohol resumption remains a …

Background Exposure to stress is potentially important in the pathway to alcohol use and
alcohol use disorders. Stressors occur at multiple time points across the life course, with …

Background: At least 60% of those treated for an alcohol use disorder will relapse. Empirical
study of the integrity of the brain reward system (BRS) is critical to understanding the …

The development of alcohol dependence is posited to involve numerous changes in brain
chemistry (ie, neurotransmission) that lead to physiological signs of withdrawal upon …

Background Limited clinical trials and case-reports yielded conflicting results regarding the
efficacy of baclofen (a GABAB agonist) in the treatment of alcohol dependence. The aim of …

Alcoholism has a profound impact on millions of people throughout the world. However, the
ability to determine if a patient needs treatment is hindered by reliance on self-reporting and …

Addictive disorders have been much investigated and many studies have underlined the
role of environmental factors such as social interaction in the vulnerability to and …

Purpose: There has been a lack of comprehensive reviews targeting specific aspects of
functioning and the difficulties faced by persons with alcohol dependence. The aim of the …

Objective: Physical pain and negative affect have been described as risk factors for alcohol
use following alcohol treatment. The current study was a secondary analysis of 2 clinical …

Substance use disorders blight the lives of millions of people and inflict a heavy financial
burden on society. There is a compelling need for new pharmacological treatments as …