Pathogenic mechanisms underlying idiopathic pulmonary fibrosis

BJ Moss, SW Ryter, IO Rosas - Annual Review of Pathology …, 2022 - annualreviews.org
The pathogenesis of idiopathic pulmonary fibrosis (IPF) involves a complex interplay of cell
types and signaling pathways. Recurrent alveolar epithelial cell (AEC) injury may occur in …

Molecular pathogenesis of pulmonary fibrosis, with focus on pathways related to TGF-β and the ubiquitin-proteasome pathway

N Inui, S Sakai, M Kitagawa - International journal of molecular sciences, 2021 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease. During
the past decade, novel pathogenic mechanisms of IPF have been elucidated that have …

PEAR1 regulates expansion of activated fibroblasts and deposition of extracellular matrix in pulmonary fibrosis

Y Geng, L Li, J Yan, K Liu, A Yang, L Zhang… - Nature …, 2022 - nature.com
Pulmonary fibrosis is a chronic interstitial lung disease that causes irreversible and
progressive lung scarring and respiratory failure. Activation of fibroblasts plays a central role …

CD38 mediates lung fibrosis by promoting alveolar epithelial cell aging

H Cui, N Xie, S Banerjee, T Dey, RM Liu… - American Journal of …, 2022 - atsjournals.org
Rationale: A prevailing paradigm recognizes idiopathic pulmonary fibrosis (IPF) originating
from various alveolar epithelial cell (AEC) injuries, and there is a growing appreciation of …

Astragalus and its formulas as a therapeutic option for fibrotic diseases: Pharmacology and mechanisms

Y Zhu, Y Chai, G Xiao, Y Liu, X Xie, W Xiao… - Frontiers in …, 2022 - frontiersin.org
Fibrosis is the abnormal deposition of extracellular matrix, characterized by accumulation of
collagen and other extracellular matrix components, which causes organ dysfunction and …

Externalized histones fuel pulmonary fibrosis via a platelet-macrophage circuit of TGFβ1 and IL-27

DR Riehl, A Sharma, J Roewe… - Proceedings of the …, 2023 - National Acad Sciences
Externalized histones erupt from the nucleus as extracellular traps, are associated with
several acute and chronic lung disorders, but their implications in the molecular …

Nintedanib inhibits endothelial mesenchymal transition in bleomycin-induced pulmonary fibrosis via focal adhesion kinase activity reduction

WK Yu, WC Chen, VYF Su, HC Shen, HH Wu… - International Journal of …, 2022 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease (ILD). Pulmonary
fibroblasts play an important role in the development of IPF. Emerging evidence indicates …

Tuberostemonine may enhance the function of the SLC7A11/glutamate antiporter to restrain the ferroptosis to alleviate pulmonary fibrosis

Y Liu, A Tang, M Liu, C Xu, F Cao, C Yang - Journal of Ethnopharmacology, 2024 - Elsevier
Ethnopharmacological relevance Stemona is a medicinal plant that has been used in China
for thousands of years to treat respiratory diseases such as cough and tuberculosis. The …

Exosomes derived from hypoxia-induced alveolar epithelial cells stimulate interstitial pulmonary fibrosis through a HOTAIRM1-dependent mechanism

L Chen, Y Yang, R Yue, X Peng, H Yu… - Laboratory …, 2022 - nature.com
Pulmonary fibrosis is the result of various diseases with no satisfactory treatment
approaches. The exosome-mediated transfer of long noncoding RNAs (lncRNAs) has been …

CCL17 drives fibroblast activation in the progression of pulmonary fibrosis by enhancing the TGF-β/Smad signaling

Q Wang, S Liu, J Min, M Yin, Y Zhang, Y Zhang… - Biochemical …, 2023 - Elsevier
Pulmonary fibrosis (PF) is a type of fatal respiratory diseases with limited therapeutic options
and poor prognosis. The chemokine CCL17 plays crucial roles in the pathogenesis of …