Genome-scale stoichiometric modeling of metabolism has become a standard systems
biology tool for modeling cellular physiology and growth. Extensions of this approach are …

Process intensification offers the potential to drastically reduce the energy consumption and
cost of producing chemicals from both bulk and distributed feedstocks. This review article …

Besides its use for efficient production of recombinant proteins the methylotrophic yeast
Pichia pastoris (syn. Komagataella spp.) has been increasingly employed as a platform to …

Genome-scale metabolic models (GEMs) enable the mathematical simulation of the
metabolism of archaea, bacteria, and eukaryotic organisms. GEMs quantitatively define a …

The reconstruction and analysis of genome-scale metabolic models constitutes a powerful
systems biology approach, with applications ranging from basic understanding of genotype …

The adverse impacts of fossil fuels on the environment, specifically climate change, have
intensified the need for finding a sustainable alternative source of energy. Numerous studies …

Most microbial communities change with time in response to changes and/or perturbations
in environmental conditions. Temporal variations in interspecies metabolic interactions …

In contrast to stoichiometric-based models, the development of large-scale kinetic models of
metabolism has been hindered by the challenge of identifying kinetic parameter values and …

Motivation Microbes are essential part of all ecosystems, influencing material flow and
shaping their surroundings. Metabolic modeling has been a useful tool and provided …

The intestinal microbiota is an ecosystem susceptible to external perturbations such as
dietary changes and antibiotic therapies. Mathematical models of microbial communities …