Sartans (angiotensin II receptor blockers, ARBs), drugs used in the treatment of
hypertension, play a principal role in addressing the global health challenge of …

Evolving therapeutic landscape through combinatorial chemistry and high throughput
screening have resulted in an increased number of poorly soluble drugs. Drug delivery …

Poor bioavailability hampers the use of curcumin and piperine as biologically active agents.
It can be improved by enhancing the solubility as well as by using bioenhancers to inhibit …

The low bioaccessibility of hesperetin and piperine hampers their application as therapeutic
agents. Piperine has the ability to improve the bioavailability of many compounds when co …

BCS class II drugs exhibit low aqueous solubility and high permeability. Such drugs often
have an incomplete or erratic absorption profile. This study aimed to predict the effects of β …

Naringin (NRG) is a water insoluble glycoside having wide range of therapeutic efficacy. Its
efficacy is limited due to its poor water solubility and bioavailability. In the current research …

Irbesartan (IRB), a selective AT1 subtype angiotensin II receptor blocker used for
management of hypertension, exhibiting low and variable oral bioavailability because of its …

Risperidone is an antipsychotic drug classified as BCS Class II with low solubility at
physiological pH and orally used in the treatment of schizophrenia. Electrospinning is one of …

Purpose The current study assessed the potential of a pneumatic 3D printer in developing a
taste-masked tablet in a single step. Metronidazole (MTZ) was chosen as the model drug …

The rational design of AT1 receptor antagonists represents a pivotal approach in the
development of therapeutic agents targeting cardiovascular pathophysiology. Sartans, a …