Simple Summary The ubiquitin proteasome system (UPS) governs the non-lysosomal
degradation of oxidized, damaged, or misfolded proteins in eukaryotic cells. Dysregulation …

Ubiquitin specific protease 7 (USP7) is one of the deubiquitinating enzymes (DUB) that
erases ubiquitin and protects substrate protein from degradation. Full activity of USP7 …

The constitutive expression of Sp eckled-100 (Sp100) is known to restrict the replication of
many clinically important DNA viruses. This pre-existing (intrinsic) immune defense to virus …

Detection of viral nucleic acids plays a critical role in the induction of intracellular host
immune defences. However, the temporal recruitment of immune regulators to infecting viral …

The Epstein-Barr virus (EBV) nuclear antigen leader protein (EBNA-LP) is the first viral
latency-associated protein produced after EBV infection of resting B cells. Its role in B cell …

Histone deacetylases (HDACs) regulate gene expression and innate immunity. Previously,
we showed that HDAC5 is degraded during Vaccinia virus (VACV) infection and is a …

The acquisition of unlimited proliferative potential is dependent on the activation of
mechanisms for telomere maintenance, which counteracts telomere shortening and the …

HSV-1 genomes are rapidly heterochromatinized following entry by host cells to limit viral
gene expression. Efficient HSV-1 genome replication requires mechanisms that de-repress …

Nuclear domains 10 (ND10), aka promyelocytic leukemia nuclear bodies (PML-NBs), are
membraneless subnuclear domains that are highly dynamic in their protein composition in …

Promyelocytic leukemia-nuclear bodies (PML-NBs) are dot-like protein assemblies and
implicated in the pathogenesis of leukemia and viral infection. PML is the scaffold protein of …