Post-translational modifications (PTMs) on tau have long been recognized as affecting
protein function and contributing to neurodegeneration. The explosion of information on …

Glycobiology: Toward Understanding the Function of Sugars | Chemical Reviews ACS ACS
Publications C&EN CAS Find my institution Log In Chemical Reviews ACS Publications …

Tau proteins belong to the family of microtubule-associated proteins. They are mainly
expressed in neurons where they play an important role in the assembly of tubulin …

O-Linked N-acetylglucosamine (O-GlcNAc) glycosylation is a dynamic modification of
eukaryotic nuclear and cytosolic proteins analogous to protein phosphorylation. We have …

Glycosylation of nuclear and cytoplasmic proteins by O-linked N-acetylglucosamine (O-
GlcNAc) monosaccharides is an abundant, ubiquitous, and transient post-translational …

The largest subunit of mammalian RNA polymerase II (RNAP II) contains at its carboxyl
terminus an unusual domain consisting of 52 tandem repeats of the consensus sequence …

Tau is a family of phosphoproteins that are important in modulating microtubule stability in
neurons. In Alzheimer's disease tau is abnormally hyperphosphorylated, no longer binds …

The majority of natural proteins contain (oligo)-saccharide side chains and therefore are
called glycoproteins. The saccharide residues are covalently linked to the protein backbone …

O-GlcNAc, the modification of Ser and Thr residues of nuclear and cytoplasmic proteins with
O-linked β-N-acetylglucosamine, is one of a growing number of posttranslational …

Protein glycosylation is more abundant and structurally diverse than all other types of post-
translational modifications combined. Protein-bound saccharides range from dynamic …