TALEN were the first easy-to-use genome editing technology and sparked the genome
editing revolution. Their application in multiple species brought targeted mutagenesis to the …

Genome editing (GE) entails the modification of specific genomic sequences in living cells
for the purpose of determining, changing, or expanding their function (s). Typically, GE …

Targeted nucleases, including zinc-finger nucleases (ZFNs), transcription activator-like
(TAL) effector nucleases (TALENs) and clustered regularly interspaced short palindromic …

Humans rely heavily on cereal grains as a key source of nutrients, hence regular
improvement of cereal crops is essential for ensuring food security. The current food crisis at …

In the realm of gene therapy, a pivotal moment arrived with Paul Berg's groundbreaking
identification of the first recombinant DNA in 1972. This achievement set the stage for future …

CAR-T cell therapy has shown remarkable promise in treating B-cell malignancies, which
has sparked optimism about its potential to treat other types of cancer as well. Nevertheless …

Safe, efficient, and broadly applicable methods for delivering site-specific nucleases into
cells are needed in order for targeted genome editing to reach its full potential for basic …

Modern biotechnology is progressed to sequence-specific, site-directed, precise, and safe
strategies for genetic manipulation. The genome-editing strategy is being proposed as one …

Transcription Activator-Like (TAL) effectors from Xanthomonas plant pathogenic bacteria can
bind to the promoter region of plant genes and induce their expression. DNA-binding …

Xanthomonas transcription activator‐like effectors (TALE s) are injected inside plant cells to
promote host susceptibility by enhancing transcription of host susceptibility genes. TALE …