PCR-based diagnosis of human fungal infections

PD Khot, DN Fredricks - Expert review of anti-infective therapy, 2009 - Taylor & Francis
PCR is a very appealing technology for the detection of human pathogens, but the detection
of fungal pathogens is particularly challenging. Fungi have cell walls that impede the …

Detection and investigation of invasive mould disease

M Cuenca-Estrella, M Bassetti… - Journal of …, 2011 - academic.oup.com
A comprehensive review of diagnostic techniques for opportunistic systemic mycoses
focused on invasive mould disease in immunocompromised patients is presented. We first …

Contribution of Galactofuranose to the Virulence of the Opportunistic Pathogen Aspergillus fumigatus

PS Schmalhorst, S Krappmann, W Vervecken… - Eukaryotic …, 2008 - Am Soc Microbiol
The filamentous fungus Aspergillus fumigatus is responsible for a lethal disease called
invasive aspergillosis that affects immunocompromised patients. This disease, like other …

Development and optimization of quantitative PCR for the diagnosis of invasive aspergillosis with bronchoalveolar lavage fluid

PD Khot, DL Ko, RC Hackman, DN Fredricks - BMC infectious diseases, 2008 - Springer
Background The diagnosis of invasive pulmonary aspergillosis (IPA) remains challenging.
Culture and histopathological examination of bronchoalveolar lavage (BAL) fluid are useful …

[HTML][HTML] The utility of galactomannan antigen in the bronchial washing and serum for diagnosing pulmonary aspergillosis

Y Kono, K Tsushima, K Yamaguchi, N Kurita… - Respiratory …, 2013 - Elsevier
Background The diagnosis of pulmonary aspergillosis is difficult because the sensitivity of
the conventional methods for the detection of Aspergillus such as culture and cytology, is …

Sinonasal aspergillosis in dogs: a review

MJ Sharman, CS Mansfield - Journal of Small Animal Practice, 2012 - Wiley Online Library
Sinonasal aspergillosis is an uncommon, yet debilitating and often frustrating condition to
treat in dogs despite years of research evaluating pathogenesis, diagnosis and treatment …

Application of galactomannan analysis and protein electrophoresis in the diagnosis of aspergillosis in avian species

C Cray, T Watson, M Rodriguez, KL Arheart - Journal of Zoo and Wildlife …, 2009 - BioOne
Previous studies support the possible application of galactomannan, a major antigen of
Aspergillus sp., to aspergillosis diagnosis in avian and other animal species. An assay is …

Performance of a standardized bronchoalveolar lavage protocol in a comprehensive cancer center: a prospective 2‐year study

F Sampsonas, DP Kontoyiannis, BF Dickey, SE Evans - Cancer, 2011 - Wiley Online Library
BACKGROUND: Flexible bronchoscopy with bronchoalveolar lavage (BAL) is performed
widely for the diagnosis of pulmonary infections in patients with cancer, but there is no …

Breaking the mould: challenging the status quo of clinical trial response definitions for invasive fungal diseases—a debate

J Maertens, M Slavin, M Hoenigl… - Journal of …, 2024 - academic.oup.com
The field of invasive fungal disease (IFD) continues to evolve rapidly as new antifungals,
including those with novel mechanisms of action, are being developed or have recently …

Invasive mold infections in pediatric cancer patients reflect heterogeneity in etiology, presentation, and outcome: a 10-year, single-institution, retrospective study

SP Georgiadou, G Pongas, NE Fitzgerald… - Journal of the …, 2012 - academic.oup.com
Background. There is scarcity of data regarding invasive mold infections (IMIs) in children
with cancer. Methods. We retrospectively identified patients (18 years old or younger) with …