Macrophages are immune cells with important roles in tissue homeostasis, inflammation and
pathologies. Hence, macrophage populations represent promising targets for modern …

Hematopoietic stem cells (HSCs) support haematopoiesis throughout life and give rise to the
whole variety of cells of the immune system. Developing in the early embryo, passing …

Haematopoietic stem cells (HSCs) arise in the embryo from the arterial endothelium through
a process known as the endothelial-to-haematopoietic transition (EHT),,–. This process …

Self-renewal and differentiation are tightly controlled to maintain haematopoietic stem cell
(HSC) homeostasis in the adult bone marrow,. During fetal development, expansion of …

Developmental deconvolution of complex organs and tissues at the level of individual cells
remains challenging. Non-invasive genetic fate mapping has been widely used, but the low …

Current dogma asserts that the foetal liver (FL) is an expansion niche for recently specified
haematopoietic stem cells (HSCs) during ontogeny. Indeed, between embryonic day of …

Hematopoietic stem and progenitor cells (HSPCs) in the bone marrow are derived from a
small population of hemogenic endothelial (HE) cells located in the major arteries of the …

Limited knowledge of cellular and molecular mechanisms underlying hematopoietic stem
cell and multipotent progenitor (HSC/MPP) expansion within their native niche has impeded …

During embryogenesis, waves of hematopoietic progenitors develop from hemogenic
endothelium (HE) prior to the emergence of self-renewing hematopoietic stem cells (HSCs) …

Hematopoietic stem cells (HSCs) in adults are believed to be born from hemogenic
endothelial cells (HECs) in mid-gestational embryos. Due to the rare and transient nature …