Acetaminophen (APAP) overdose is the clinically most relevant drug hepatotoxicity in
western countries, and, because of translational relevance of animal models, APAP is …

Acetaminophen (APAP) is one of the most popular and safe pain medications worldwide.
However, due to its wide availability, it is frequently implicated in intentional or unintentional …

Drug-induced acute liver failure carries a high morbidity and mortality rate. Acetaminophen
overdose is the number one cause of acute liver failure and remains a major problem in …

Acetaminophen (APAP) is one of the most widely used drugs. Though safe at therapeutic
doses, overdose causes mitochondrial dysfunction and centrilobular necrosis in the liver …

Summary ARID1A, an SWI/SNF chromatin-remodeling gene, is commonly mutated in cancer
and hypothesized to be tumor suppressive. In some hepatocellular carcinoma patients …

Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the US,
and decades of intense study of its pathogenesis resulted in the development of the antidote …

Background: Drug-induced liver injury is a rare but serious clinical problem. A number of
drugs can cause severe liver injury and acute liver failure at therapeutic doses in a very …

Acetaminophen/paracetamol is the most widely used drug of the world. At the same time, it is
probably one of the most dangerous compounds in medical use, causing hundreds of …

Background & Aims Acetaminophen (APAP)-induced liver injury is the most frequent cause
of acute liver failure in the US and many other countries. Metabolism of APAP results in …

Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the
United States and mechanisms of liver injury induced by APAP overdose have been the …