Although the classic activities of p53 including induction of cell-cycle arrest, senescence,
and apoptosis are well accepted as critical barriers to cancer development, accumulating …

Doxorubicin (DOX) is the most widely used anthracycline anticancer agent; however, its
cardiotoxicity limits its clinical efficacy. Numerous studies have elucidated the mechanisms …

Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases with
limited treatment options. Moreover, its prevalence is doubled in type 2 diabetes mellitus …

Reprogrammed cell metabolism is a well-accepted hallmark of cancer. Metabolism changes
provide energy and precursors for macromolecule biosynthesis to satisfy the survival needs …

The p53 family of tumor suppressors, which includes p53, p63, and p73, has a critical role in
many biological processes, such as cell cycle arrest, apoptosis, and differentiation. In …

Pyruvate kinase M2 (PKM2) is a glycolytic enzyme that translocates to the nucleus to
regulate transcription factors in different tissues or pathologic states. Although studied …

Background Trametinib is a MEK1 (mitogen-activated extracellular signal-related kinase
kinase 1) inhibitor used in the treatment of BRAF (rapid accelerated fibrosarcoma B-type) …

Hyperglycemia, lipotoxicity, and insulin resistance are known to increase the secretion of
extracellular matrix from cardiac fibroblasts as well as the activation of paracrine signaling …

Cancer is the leading cause of death worldwide, and the number of cancer-related deaths is
expected to increase. Common types of cancer include skin, breast, lung, prostate, and …