Multifaceted behavior of PEST sequence enriched nuclear proteins in cancer biology and role in gene therapy

M Sarfraz, A Afzal, S Khattak… - Journal of Cellular …, 2021 - Wiley Online Library
The amino acid sequence enriched with proline (P), glutamic acid (E), serine (S), and
threonine (T)(PEST) is a signal‐transducing agent providing unique features to its substrate …

Taking a holistic view of PEST‐containing nuclear protein (PCNP) in cancer biology

A Afzal, M Sarfraz, GL Li, SP Ji, SF Duan… - Cancer …, 2019 - Wiley Online Library
Polypeptide sequences enriched with proline (P), glutamic acid (E), aspartic acid (D) and
serine (S)/threonine (T)(PEST) have been reported to be the most abundant and frequently …

Optimization of weight ratio for DSPE-PEG/TPGS hybrid micelles to improve drug retention and tumor penetration

Y Jin, Z Wu, C Li, W Zhou, JP Shaw, BC Baguley… - Pharmaceutical …, 2018 - Springer
Purpose To enhance therapeutic efficacy and prevent phlebitis caused by Asulacrine (ASL)
precipitation post intravenous injection, ASL-loaded hybrid micelles with size below 40 nm …

Expedient synthesis and anticancer evaluation of dual‐action 9‐anilinoacridine methyl triazene chimeras

D Walunj, K Egarmina, H Tuchinsky… - Chemical Biology & …, 2021 - Wiley Online Library
The efficient synthesis of molecular hybrids including a DNA‐intercalating 9‐anilinoacridine
(9‐AnA) core and a methyl triazene DNA‐methylating moiety is described. Nucleophilic …

Synthesis and biological activities of imidazolium acridines and their silver complexes/Olla HS Sharhan

HS Olla - 2020 - studentsrepo.um.edu.my
In the present study, a series of acridine-based imidazolium ligands were synthesized by the
Menshutkin reaction and used for the preparation of the silver complexes. The structures …

Synthesis and Biological Activities of Imidazolium Acridines and Their Silver Complexes

OHS Sharhan - 2020 - search.proquest.com
In the present study, a series of acridine-based imidazolium ligands were synthesized by the
Menshutkin reaction and used for the preparation of the silver complexes. The structures …

Nomenclature

J Ježek, J Hlaváček, J Šebestík, J Ježek… - … Applications of Acridines …, 2017 - Springer
Acridines have been known since 1870. Thus, their nomenclature has developed for long
time. There are many numbering systems from which we have selected two most important …

Pharmacokinetics and Metabolism of Acridine Drugs

J Ježek, J Hlaváček, J Šebestík, J Ježek… - … Applications of Acridines …, 2017 - Springer
Pharmacokinetic reasons have strong influence on applications of acridine drugs. Balancing
of processes such as absorption, distribution, metabolism and excretion (ADME) is …