Poor targeting of therapeutics leading to severe adverse effects on normal tissues is
considered one of the obstacles in cancer therapy. To help overcome this, nanoscale drug …

Cancer microenvironment is critical for tumorigenesis and cancer progression. The
extracellular matrix (ECM) interacts with tumor and stromal cells to promote cancer cells …

Nitric oxide (NO), a gaseous transmitter extensively present in the human body, regulates
vascular relaxation, immune response, inflammation, neurotransmission, and other crucial …

Anticancer nanomedicines have been proven effective in mitigating the side effects of
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …

Insufficient tumor accumulation and distribution of photosensitizers as well as low antitumor
immunity severely restrict the therapeutic efficacy of photothermal therapy (PTT). Cancer …

Biomolecule-based nanostructures are inherently multifunctional and harbour diverse
biological activities, which can be explored for cancer nanomedicine. The supramolecular …

Nanomedicine holds promise to enhance cancer immunotherapy; however, its potential to
elicit highly specific anti-tumor immunity without compromising immune tolerance has yet to …

Efforts to develop anti-cancer therapies have largely focused on targeting the epithelial
compartment, despite the presence of non-neoplastic stromal components that substantially …

Multiple nanotherapeutics have been approved for patients with cancer, but their effects on
survival have been modest and, in some examples, less than those of other approved …

Lipid nanoparticle-mediated RNA delivery holds great potential to treat various liver
diseases. However, targeted delivery of RNA therapeutics to activated liver-resident …