Highlights•Novel devices are posing challenges to existing spike sorting pipelines.•Spike
sorting methodology is expanding to handle thousands to millions of neurons.•Multi-stage …

Understanding the detailed dynamics of neuronal networks will require the simultaneous
measurement of spike trains from hundreds of neurons (or more). Currently, approaches to …

Advances in silicon probe technology mean that in vivo electrophysiological recordings from
hundreds of channels will soon become commonplace. To interpret these recordings we …

Developments in microfabrication technology have enabled the production of neural
electrode arrays with hundreds of closely spaced recording sites, and electrodes with …

Mathematical and statistical models have played important roles in neuroscience, especially
by describing the electrical activity of neurons recorded individually, or collectively across …

ABSTRACT A natural Bayesian approach for mixture models with an unknown number of
components is to take the usual finite mixture model with symmetric Dirichlet weights, and …

Cluster analysis faces two problems in high dimensions: the “curse of dimensionality” that
can lead to overfitting and poor generalization performance and the sheer time taken for …

Spike sorting is a crucial step in electrophysiological studies of neuronal activity. While many
spike sorting packages are available, there is little consensus about which are most …

Objective. Brain–computer interfaces (BCIs) are a promising technology for restoring motor
ability to paralyzed patients. Spiking-based BCIs have successfully been used in clinical …

Brain signals measured over a series of experiments have inherent variability because of
different physical and mental conditions among multiple subjects and sessions. Such …