Depression in neurodegenerative diseases: Common mechanisms and current treatment options

CPC Galts, LEB Bettio, DC Jewett, CC Yang… - Neuroscience & …, 2019 - Elsevier
Major depressive disorder (MDD) is a highly prevalent psychiatric disorder and a major
cause of disability worldwide. This neurological condition is commonly associated with …

Implications of microbe-derived ɣ-aminobutyric acid (GABA) in gut and brain barrier integrity and GABAergic signaling in Alzheimer's disease

KA Conn, EM Borsom, EK Cope - Gut microbes, 2024 - Taylor & Francis
The gut microbial ecosystem communicates bidirectionally with the brain in what is known
as the gut-microbiome-brain axis. Bidirectional signaling occurs through several pathways …

CB2 receptor and amyloid pathology in frontal cortex of Alzheimer's disease patients

M Solas, PT Francis, R Franco, MJ Ramirez - Neurobiology of aging, 2013 - Elsevier
The cannabinoid system seems to play an important role in various neurodegenerative
diseases including Alzheimer's disease (AD). The relationship of cannabinoid receptors …

Age-related changes in the central auditory system

L Ouda, O Profant, J Syka - Cell and tissue research, 2015 - Springer
Aging is accompanied by the deterioration of hearing that complicates our understanding of
speech, especially in noisy environments. This deficit is partially caused by the loss of hair …

Principles and management of neuropsychiatric symptoms in Alzheimer's dementia

MA Nowrangi, CG Lyketsos, PB Rosenberg - Alzheimer's research & …, 2015 - Springer
Neuropsychiatric symptoms of Alzheimer's disease (NPS-AD) are highly prevalent and lead
to poor medical and functional outcomes. In spite of the burdensome nature of NPS-AD, we …

Depression in Alzheimer's disease: epidemiology, mechanisms, and management

S Chi, JT Yu, MS Tan, L Tan - Journal of Alzheimer's disease, 2014 - content.iospress.com
Depression occurs with a high prevalence of up to 50% in patients with Alzheimer's disease
(AD) and increases the caregivers' burden. Depression symptoms can precede clinical …

Physical exercise improves synaptic dysfunction and recovers the loss of survival factors in 3xTg-AD mouse brain

S Revilla, C Suñol, Y García-Mesa, L Giménez-Llort… - …, 2014 - Elsevier
Physical exercise has become a potentially beneficial therapy for reducing
neurodegeneration symptoms in Alzheimer's disease. Previous studies have shown that …

Social vs. environmental stress models of depression from a behavioural and neurochemical approach

E Venzala, AL Garcia-Garcia, N Elizalde… - European …, 2013 - Elsevier
Major depression is a mental disorder often preceded by exposure to chronic stress or
stressful life events. Recently, animal models based on social conflict such as chronic social …

Enhanced anxiety, depressive‐like behaviour and impaired recognition memory in mice with reduced expression of the vesicular glutamate transporter 1 (VGLUT1)

RM Tordera, S Totterdell, SM Wojcik… - European Journal of …, 2007 - Wiley Online Library
Three isoforms of a vesicular glutamate transporter (VGLUT1–3) have been identified. Of
these, VGLUT1 is the major isoform in the cerebral cortex and hippocampus where it is …

A metabolomic study of the CRND8 transgenic mouse model of Alzheimer's disease

RM Salek, J Xia, A Innes, BC Sweatman… - Neurochemistry …, 2010 - Elsevier
Alzheimer's disease is the most common neurodegenerative disease of the central nervous
system characterized by a progressive loss in memory and deterioration of cognitive …